The role of red blood cell deformability and Na,K-ATPase function in selected risk factors of cardiovascular diseases in humans: focus on hypertension, diabetes mellitus and hypercholesterolemia
Deformability of red blood cells (RBC) is the ability of RBC to change their shape in order to pass through narrow capillaries in circulation. Deterioration in deformability of RBC contributes to alterations in microcirculatory blood flow and delivery of oxygen to tissues. Several factors are respon...
Gespeichert in:
| Veröffentlicht in: | Physiological research 2016-01, Vol.65 Suppl 1, p.S43-S54 |
|---|---|
| Hauptverfasser: | , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | S54 |
|---|---|
| container_issue | |
| container_start_page | S43 |
| container_title | Physiological research |
| container_volume | 65 Suppl 1 |
| creator | Radosinska, J Vrbjar, N |
| description | Deformability of red blood cells (RBC) is the ability of RBC to change their shape in order to pass through narrow capillaries in circulation. Deterioration in deformability of RBC contributes to alterations in microcirculatory blood flow and delivery of oxygen to tissues. Several factors are responsible for maintenance of RBC deformability. One of them is the Na,K-ATPase known as crucial enzyme in maintenance of intracellular ionic homeostasis affecting thus regulation of cellular volume and consequently RBC deformability. Decreased deformability of RBC has been found to be the marker of adverse outcomes in cardiovascular diseases (CVD) and the presence of cardiovascular risk factors influences rheological properties of the blood. This review summarizes knowledge concerning the RBC deformability in connection with selected risk factors of CVD, including hypertension, hyperlipidemia, and diabetes mellitus, based exclusively on papers from human studies. We attempted to provide an update on important issues regarding the role of Na,K-ATPase in RBC deformability. In patients suffering from hypertension as well as diabetes mellitus the Na,K-ATPase appears to be responsible for the changes leading to alterations in RBC deformability. The triggering factor for changes of RBC deformability during hypercholesterolemia seems to be the increased content of cholesterol in erythrocyte membranes. |
| doi_str_mv | 10.33549/physiolres.933402 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_journals_1827832322</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>4211241231</sourcerecordid><originalsourceid>FETCH-LOGICAL-c408t-68d2ecea2aa68d876019903e169b0c66da3fbf9248dd82f84ddb0efe5e422a4d3</originalsourceid><addsrcrecordid>eNpFkc1O3DAUha2KqgyUF-gCWWJLqGOHxO4OofIjEHQxrKMb-1pj6sSD7VSa1-uT1cNAWfnK-s65xz6EfKvZmRDnjfq-Xm2SCz5iOlNCNIx_IotaMl4p1Yk9smCy5ZVsmNwnByk9M8Y71okvZJ93bSOUUAvyd7lCGoNHGiyNaOjgQzBUo_fUoA1xhMF5lzcUJkMf4PSuulj-goTUzpPOLkzUTTShR52LOrr0m1rQOcS0ddQQjQt_IOnZQ6TGJSzatNWs5hGm9IPaoOfClovNGmPGqTxpOi0oDJgLOpYoLhdkG-CV0auSN2Xcxh4dfCWfLfiER2_nIXm6-rm8vKnuH69vLy_uK11-IFetNBw1Agcoo-xaVivFBNatGphuWwPCDlbxRhojuZWNMQNDi-fYcA6NEYfkZOe7juFlLgH65zDHqazsa8k7KbjgvFB8R-kYUopo-3V0I8RNX7P-tbb-o7Z-V1sRHb9Zz8OI5r_kvSfxDzGenAM</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1827832322</pqid></control><display><type>article</type><title>The role of red blood cell deformability and Na,K-ATPase function in selected risk factors of cardiovascular diseases in humans: focus on hypertension, diabetes mellitus and hypercholesterolemia</title><source>MEDLINE</source><source>DOAJ Directory of Open Access Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><creator>Radosinska, J ; Vrbjar, N</creator><creatorcontrib>Radosinska, J ; Vrbjar, N</creatorcontrib><description>Deformability of red blood cells (RBC) is the ability of RBC to change their shape in order to pass through narrow capillaries in circulation. Deterioration in deformability of RBC contributes to alterations in microcirculatory blood flow and delivery of oxygen to tissues. Several factors are responsible for maintenance of RBC deformability. One of them is the Na,K-ATPase known as crucial enzyme in maintenance of intracellular ionic homeostasis affecting thus regulation of cellular volume and consequently RBC deformability. Decreased deformability of RBC has been found to be the marker of adverse outcomes in cardiovascular diseases (CVD) and the presence of cardiovascular risk factors influences rheological properties of the blood. This review summarizes knowledge concerning the RBC deformability in connection with selected risk factors of CVD, including hypertension, hyperlipidemia, and diabetes mellitus, based exclusively on papers from human studies. We attempted to provide an update on important issues regarding the role of Na,K-ATPase in RBC deformability. In patients suffering from hypertension as well as diabetes mellitus the Na,K-ATPase appears to be responsible for the changes leading to alterations in RBC deformability. The triggering factor for changes of RBC deformability during hypercholesterolemia seems to be the increased content of cholesterol in erythrocyte membranes.</description><identifier>ISSN: 0862-8408</identifier><identifier>EISSN: 1802-9973</identifier><identifier>DOI: 10.33549/physiolres.933402</identifier><identifier>PMID: 27643939</identifier><language>eng</language><publisher>Czech Republic: Institute of Physiology</publisher><subject>Cardiovascular disease ; Cholesterol ; Diabetes ; Diabetes Mellitus - blood ; Diabetes Mellitus - enzymology ; Enzymes ; Erythrocytes ; Erythrocytes - cytology ; Erythrocytes - enzymology ; Homeostasis ; Humans ; Hypercholesterolemia - blood ; Hypercholesterolemia - enzymology ; Hypertension ; Hypertension - blood ; Hypertension - enzymology ; Hypotheses ; Mortality ; Plasma ; Risk Factors ; Signal transduction ; Sodium-Potassium-Exchanging ATPase - metabolism ; Studies ; Womens health</subject><ispartof>Physiological research, 2016-01, Vol.65 Suppl 1, p.S43-S54</ispartof><rights>Copyright Institute of Physiology 2016</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c408t-68d2ecea2aa68d876019903e169b0c66da3fbf9248dd82f84ddb0efe5e422a4d3</citedby><cites>FETCH-LOGICAL-c408t-68d2ecea2aa68d876019903e169b0c66da3fbf9248dd82f84ddb0efe5e422a4d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,865,27929,27930</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27643939$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Radosinska, J</creatorcontrib><creatorcontrib>Vrbjar, N</creatorcontrib><title>The role of red blood cell deformability and Na,K-ATPase function in selected risk factors of cardiovascular diseases in humans: focus on hypertension, diabetes mellitus and hypercholesterolemia</title><title>Physiological research</title><addtitle>Physiol Res</addtitle><description>Deformability of red blood cells (RBC) is the ability of RBC to change their shape in order to pass through narrow capillaries in circulation. Deterioration in deformability of RBC contributes to alterations in microcirculatory blood flow and delivery of oxygen to tissues. Several factors are responsible for maintenance of RBC deformability. One of them is the Na,K-ATPase known as crucial enzyme in maintenance of intracellular ionic homeostasis affecting thus regulation of cellular volume and consequently RBC deformability. Decreased deformability of RBC has been found to be the marker of adverse outcomes in cardiovascular diseases (CVD) and the presence of cardiovascular risk factors influences rheological properties of the blood. This review summarizes knowledge concerning the RBC deformability in connection with selected risk factors of CVD, including hypertension, hyperlipidemia, and diabetes mellitus, based exclusively on papers from human studies. We attempted to provide an update on important issues regarding the role of Na,K-ATPase in RBC deformability. In patients suffering from hypertension as well as diabetes mellitus the Na,K-ATPase appears to be responsible for the changes leading to alterations in RBC deformability. The triggering factor for changes of RBC deformability during hypercholesterolemia seems to be the increased content of cholesterol in erythrocyte membranes.</description><subject>Cardiovascular disease</subject><subject>Cholesterol</subject><subject>Diabetes</subject><subject>Diabetes Mellitus - blood</subject><subject>Diabetes Mellitus - enzymology</subject><subject>Enzymes</subject><subject>Erythrocytes</subject><subject>Erythrocytes - cytology</subject><subject>Erythrocytes - enzymology</subject><subject>Homeostasis</subject><subject>Humans</subject><subject>Hypercholesterolemia - blood</subject><subject>Hypercholesterolemia - enzymology</subject><subject>Hypertension</subject><subject>Hypertension - blood</subject><subject>Hypertension - enzymology</subject><subject>Hypotheses</subject><subject>Mortality</subject><subject>Plasma</subject><subject>Risk Factors</subject><subject>Signal transduction</subject><subject>Sodium-Potassium-Exchanging ATPase - metabolism</subject><subject>Studies</subject><subject>Womens health</subject><issn>0862-8408</issn><issn>1802-9973</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNpFkc1O3DAUha2KqgyUF-gCWWJLqGOHxO4OofIjEHQxrKMb-1pj6sSD7VSa1-uT1cNAWfnK-s65xz6EfKvZmRDnjfq-Xm2SCz5iOlNCNIx_IotaMl4p1Yk9smCy5ZVsmNwnByk9M8Y71okvZJ93bSOUUAvyd7lCGoNHGiyNaOjgQzBUo_fUoA1xhMF5lzcUJkMf4PSuulj-goTUzpPOLkzUTTShR52LOrr0m1rQOcS0ddQQjQt_IOnZQ6TGJSzatNWs5hGm9IPaoOfClovNGmPGqTxpOi0oDJgLOpYoLhdkG-CV0auSN2Xcxh4dfCWfLfiER2_nIXm6-rm8vKnuH69vLy_uK11-IFetNBw1Agcoo-xaVivFBNatGphuWwPCDlbxRhojuZWNMQNDi-fYcA6NEYfkZOe7juFlLgH65zDHqazsa8k7KbjgvFB8R-kYUopo-3V0I8RNX7P-tbb-o7Z-V1sRHb9Zz8OI5r_kvSfxDzGenAM</recordid><startdate>20160101</startdate><enddate>20160101</enddate><creator>Radosinska, J</creator><creator>Vrbjar, N</creator><general>Institute of Physiology</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>4T-</scope><scope>4U-</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>BYOGL</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M7P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope></search><sort><creationdate>20160101</creationdate><title>The role of red blood cell deformability and Na,K-ATPase function in selected risk factors of cardiovascular diseases in humans: focus on hypertension, diabetes mellitus and hypercholesterolemia</title><author>Radosinska, J ; Vrbjar, N</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c408t-68d2ecea2aa68d876019903e169b0c66da3fbf9248dd82f84ddb0efe5e422a4d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Cardiovascular disease</topic><topic>Cholesterol</topic><topic>Diabetes</topic><topic>Diabetes Mellitus - blood</topic><topic>Diabetes Mellitus - enzymology</topic><topic>Enzymes</topic><topic>Erythrocytes</topic><topic>Erythrocytes - cytology</topic><topic>Erythrocytes - enzymology</topic><topic>Homeostasis</topic><topic>Humans</topic><topic>Hypercholesterolemia - blood</topic><topic>Hypercholesterolemia - enzymology</topic><topic>Hypertension</topic><topic>Hypertension - blood</topic><topic>Hypertension - enzymology</topic><topic>Hypotheses</topic><topic>Mortality</topic><topic>Plasma</topic><topic>Risk Factors</topic><topic>Signal transduction</topic><topic>Sodium-Potassium-Exchanging ATPase - metabolism</topic><topic>Studies</topic><topic>Womens health</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Radosinska, J</creatorcontrib><creatorcontrib>Vrbjar, N</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Docstoc</collection><collection>University Readers</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>Proquest Central</collection><collection>Natural Science Collection</collection><collection>East Europe, Central Europe Database</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><jtitle>Physiological research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Radosinska, J</au><au>Vrbjar, N</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The role of red blood cell deformability and Na,K-ATPase function in selected risk factors of cardiovascular diseases in humans: focus on hypertension, diabetes mellitus and hypercholesterolemia</atitle><jtitle>Physiological research</jtitle><addtitle>Physiol Res</addtitle><date>2016-01-01</date><risdate>2016</risdate><volume>65 Suppl 1</volume><spage>S43</spage><epage>S54</epage><pages>S43-S54</pages><issn>0862-8408</issn><eissn>1802-9973</eissn><abstract>Deformability of red blood cells (RBC) is the ability of RBC to change their shape in order to pass through narrow capillaries in circulation. Deterioration in deformability of RBC contributes to alterations in microcirculatory blood flow and delivery of oxygen to tissues. Several factors are responsible for maintenance of RBC deformability. One of them is the Na,K-ATPase known as crucial enzyme in maintenance of intracellular ionic homeostasis affecting thus regulation of cellular volume and consequently RBC deformability. Decreased deformability of RBC has been found to be the marker of adverse outcomes in cardiovascular diseases (CVD) and the presence of cardiovascular risk factors influences rheological properties of the blood. This review summarizes knowledge concerning the RBC deformability in connection with selected risk factors of CVD, including hypertension, hyperlipidemia, and diabetes mellitus, based exclusively on papers from human studies. We attempted to provide an update on important issues regarding the role of Na,K-ATPase in RBC deformability. In patients suffering from hypertension as well as diabetes mellitus the Na,K-ATPase appears to be responsible for the changes leading to alterations in RBC deformability. The triggering factor for changes of RBC deformability during hypercholesterolemia seems to be the increased content of cholesterol in erythrocyte membranes.</abstract><cop>Czech Republic</cop><pub>Institute of Physiology</pub><pmid>27643939</pmid><doi>10.33549/physiolres.933402</doi><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0862-8408 |
| ispartof | Physiological research, 2016-01, Vol.65 Suppl 1, p.S43-S54 |
| issn | 0862-8408 1802-9973 |
| language | eng |
| recordid | cdi_proquest_journals_1827832322 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Cardiovascular disease Cholesterol Diabetes Diabetes Mellitus - blood Diabetes Mellitus - enzymology Enzymes Erythrocytes Erythrocytes - cytology Erythrocytes - enzymology Homeostasis Humans Hypercholesterolemia - blood Hypercholesterolemia - enzymology Hypertension Hypertension - blood Hypertension - enzymology Hypotheses Mortality Plasma Risk Factors Signal transduction Sodium-Potassium-Exchanging ATPase - metabolism Studies Womens health |
| title | The role of red blood cell deformability and Na,K-ATPase function in selected risk factors of cardiovascular diseases in humans: focus on hypertension, diabetes mellitus and hypercholesterolemia |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-14T16%3A45%3A02IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20role%20of%20red%20blood%20cell%20deformability%20and%20Na,K-ATPase%20function%20in%20selected%20risk%20factors%20of%20cardiovascular%20diseases%20in%20humans:%20focus%20on%20hypertension,%20diabetes%20mellitus%20and%20hypercholesterolemia&rft.jtitle=Physiological%20research&rft.au=Radosinska,%20J&rft.date=2016-01-01&rft.volume=65%20Suppl%201&rft.spage=S43&rft.epage=S54&rft.pages=S43-S54&rft.issn=0862-8408&rft.eissn=1802-9973&rft_id=info:doi/10.33549/physiolres.933402&rft_dat=%3Cproquest_cross%3E4211241231%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1827832322&rft_id=info:pmid/27643939&rfr_iscdi=true |