High Intrapatient Variability of Tacrolimus Concentrations Predicts Accelerated Progression of Chronic Histologic Lesions in Renal Recipients

High intrapatient variability (IPV) of tacrolimus concentrations is increasingly recognized as a predictor of poor outcome in solid organ recipients. How it relates to evolution of histology has not been explored. We analyzed tacrolimus IPV using the coefficient of variability (CV) from months 6–12...

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Veröffentlicht in:	American journal of transplantation 2016-10, Vol.16 (10), p.2954-2963
Hauptverfasser:	Vanhove, T., Vermeulen, T., Annaert, P., Lerut, E., Kuypers, D. R. J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Atrophy - drug therapy Atrophy - etiology Atrophy - pathology calcineurin inhibitor: tacrolimus clinical research/practice Disease Progression Female fibrosis Fibrosis - drug therapy Fibrosis - etiology Fibrosis - pathology Follow-Up Studies Glomerular Filtration Rate Graft Rejection - drug therapy Graft Rejection - etiology Graft Rejection - pathology Graft Survival - drug effects Humans immunosuppressant immunosuppression/immune modulation Immunosuppressive Agents - therapeutic use kidney (allograft) function/dysfunction Kidney Failure, Chronic - surgery Kidney Function Tests Kidney Transplantation - adverse effects kidney transplantation/nephrology Male Middle Aged pharmacokinetics/pharmacodynamics pharmacology Prognosis Retrospective Studies Risk Factors Tacrolimus - therapeutic use Transplantation, Homologous
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