Fast Efficient and General PASE Approach to Medicinally Relevant 4H,5H-Pyrano-[4,3-b]pyran-5-one and 4,6-Dihydro-5H-pyrano-[3,2-c]pyridine-5-one Scaffolds

The general ‘on‐solvent’ PASE approach was found to be medicinally relevant for 4H,5H‐pyrano[4,3‐b]pyran‐5‐one and 4,6‐dihydro‐5H‐pyrano[3,2‐c]pyridine‐5‐one scaffolds. Ammonium acetate‐catalyzed multicomponent reaction of aldehydes and two different C–H acids in the presence of small amounts of EtO...

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Veröffentlicht in:	Helvetica chimica acta 2016-09, Vol.99 (9), p.724-731
Hauptverfasser:	Elinson, Michail N., Ryzhkov, Fedor V., Nasybullin, Ruslan F., Vereshchagin, Anatoly N., Egorov, Mikhail P.
Format:	Artikel
Sprache:	eng
Schlagworte:	4-Hydroxy-1-methylquinolin-2(1H)-one 4-Hydroxy-6-methyl-2H-pyran-2-one Coumarin Malononitrile Multicomponent reactions
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creator	Elinson, Michail N. Ryzhkov, Fedor V. Nasybullin, Ruslan F. Vereshchagin, Anatoly N. Egorov, Mikhail P.
description	The general ‘on‐solvent’ PASE approach was found to be medicinally relevant for 4H,5H‐pyrano[4,3‐b]pyran‐5‐one and 4,6‐dihydro‐5H‐pyrano[3,2‐c]pyridine‐5‐one scaffolds. Ammonium acetate‐catalyzed multicomponent reaction of aldehydes and two different C–H acids in the presence of small amounts of EtOH results in fast (3 – 15 min) and efficient formation of scaffolds, promising for many diverse oriented medical applications.
doi_str_mv	10.1002/hlca.201600150
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subjects	4-Hydroxy-1-methylquinolin-2(1H)-one 4-Hydroxy-6-methyl-2H-pyran-2-one Coumarin Malononitrile Multicomponent reactions
title	Fast Efficient and General PASE Approach to Medicinally Relevant 4H,5H-Pyrano-[4,3-b]pyran-5-one and 4,6-Dihydro-5H-pyrano-[3,2-c]pyridine-5-one Scaffolds
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