A Concise Organocatalytic Synthesis of 3-Deoxy-2-ulosonic Acids through Cinchona-Alkaloid-Promoted Aldol Reactions of Pyruvate

Direct cross‐aldol reactions of a pyruvate ester with chiral aldehydes, mediated by purely organic catalysts, is described as a crucial step in the synthesis of ulosonic acids. Cinchona alkaloids containing a tertiary amine group efficiently promote direct aldol reactions of a sterically hindered py...

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Veröffentlicht in:	European journal of organic chemistry 2016-09, Vol.2016 (25), p.4394-4403
Hauptverfasser:	Molenda, Marta A., Baś, Sebastian, Mlynarski, Jacek
Format:	Artikel
Sprache:	eng
Schlagworte:	Acids Aldol reactions Asymmetric synthesis Biomimetic synthesis Carbohydrates Organocatalysis
Online-Zugang:	Volltext
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