Pre-treatment VD levels and VDR receptors as potential predictors of occurrence and overall survival in paediatric patients with solid tumours—a single institution pilot study

Recently, vitamin D has been recognized as an important player in the immune system, and multiple studies suggested its involvement in cancer, too. The aims of this study were to investigate selected single nucleotide polymorphisms (SNPs) in the VDR gene, BsmI (rs1544410; A > G), FokI (rs 2228570...

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Veröffentlicht in:Tumor biology 2016-07, Vol.37 (7), p.9209-9219
Hauptverfasser: Bienertová-Vašků, Julie, Drábová, Klára, Zlámal, Filip, Tomandl, Josef, Kýr, Michal, Šplíchal, Zbyněk, Štěrba, Jaroslav
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container_end_page 9219
container_issue 7
container_start_page 9209
container_title Tumor biology
container_volume 37
creator Bienertová-Vašků, Julie
Drábová, Klára
Zlámal, Filip
Tomandl, Josef
Kýr, Michal
Šplíchal, Zbyněk
Štěrba, Jaroslav
description Recently, vitamin D has been recognized as an important player in the immune system, and multiple studies suggested its involvement in cancer, too. The aims of this study were to investigate selected single nucleotide polymorphisms (SNPs) in the VDR gene, BsmI (rs1544410; A > G), FokI (rs 2228570; C > T), TaqI (rs731236; T > C), ApaI (rs 7975232; C > T) and Cdx-2 (rs11568820; A > G), and to evaluate their possible predictive role for outcomes in patients with paediatric solid tumours. A total of 111 children with paediatric solid tumours were enrolled at the Department of Paediatric Oncology, University Hospital Brno (Brno, Czech Republic) along with a control population of 787 adults; all study subjects were available for genotyping of selected SNPs, and the prediagnostic levels of 25-hydroxycholecalciferol (25(OH)D3) and 1,25-dihydroxycholecalciferol (1,25(OH)2D3) were measured in the cases, too. In FokI, the heterozygote CT genotype was weakly associated with a decreased risk of paediatric solid cancer occurrence 0.82 (0.53–1.28), while the CC genotype was associated with a decreased risk of 0.58 (0.30–1.09), p  = 0.09. The 1,25(OH)2D3 prediagnostic levels were indicative of the overall survival in the cases ( β  = −0.012, HR 0.988, 95 % CI (0.978–0.998), while higher prediagnostic levels of 1,25(OH)2D3 were associated with a statistically significant increase in overall mortality. We observed multiple effects of the alleles of the investigated polymorphisms and of 1,25(OH)2D3 on overall survival, regardless of the underlying disease.
doi_str_mv 10.1007/s13277-016-4820-9
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The aims of this study were to investigate selected single nucleotide polymorphisms (SNPs) in the VDR gene, BsmI (rs1544410; A &gt; G), FokI (rs 2228570; C &gt; T), TaqI (rs731236; T &gt; C), ApaI (rs 7975232; C &gt; T) and Cdx-2 (rs11568820; A &gt; G), and to evaluate their possible predictive role for outcomes in patients with paediatric solid tumours. A total of 111 children with paediatric solid tumours were enrolled at the Department of Paediatric Oncology, University Hospital Brno (Brno, Czech Republic) along with a control population of 787 adults; all study subjects were available for genotyping of selected SNPs, and the prediagnostic levels of 25-hydroxycholecalciferol (25(OH)D3) and 1,25-dihydroxycholecalciferol (1,25(OH)2D3) were measured in the cases, too. In FokI, the heterozygote CT genotype was weakly associated with a decreased risk of paediatric solid cancer occurrence 0.82 (0.53–1.28), while the CC genotype was associated with a decreased risk of 0.58 (0.30–1.09), p  = 0.09. The 1,25(OH)2D3 prediagnostic levels were indicative of the overall survival in the cases ( β  = −0.012, HR 0.988, 95 % CI (0.978–0.998), while higher prediagnostic levels of 1,25(OH)2D3 were associated with a statistically significant increase in overall mortality. We observed multiple effects of the alleles of the investigated polymorphisms and of 1,25(OH)2D3 on overall survival, regardless of the underlying disease.</abstract><cop>Dordrecht</cop><pub>Springer Netherlands</pub><pmid>26768618</pmid><doi>10.1007/s13277-016-4820-9</doi><tpages>11</tpages></addata></record>
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subjects Adolescent
Alleles
Biomedical and Life Sciences
Biomedicine
Cancer
Cancer Research
Child
Child, Preschool
Female
Gene Frequency - genetics
Genetic Association Studies - methods
Genetic Predisposition to Disease - genetics
Genotype
Humans
Male
Medical prognosis
Neoplasms - genetics
Original Article
Pediatrics
Pilot Projects
Polymorphism, Single Nucleotide - genetics
Receptors, Calcitriol - genetics
Survival analysis
Vitamin D
Vitamin D - blood
title Pre-treatment VD levels and VDR receptors as potential predictors of occurrence and overall survival in paediatric patients with solid tumours—a single institution pilot study
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