Structural basis of metallo-[beta]-lactamase, serine-[beta]-lactamase and penicillin-binding protein inhibition by cyclic boronates

β-Lactamases enable resistance to almost all β-lactam antibiotics. Pioneering work revealed that acyclic boronic acids can act as 'transition state analogue' inhibitors of nucleophilic serine enzymes, including serine-β-lactamases. Here we report biochemical and biophysical analyses reveal...

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Veröffentlicht in:	Nature communications 2016-08, Vol.7, p.12406
Hauptverfasser:	Brem, Jürgen, Cain, Ricky, Cahill, Samuel, Mcdonough, Michael A, Clifton, Ian J, Jiménez-castellanos, Juan-carlos, Avison, Matthew B, Spencer, James, Fishwick, Colin W G, Schofield, Christopher J
Format:	Artikel
Sprache:	eng
Schlagworte:	Acids Antibiotics Enzymes Penicillin Proteins
Online-Zugang:	Volltext
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