IgE-Mediated Reaction to Metamizole: Evaluation of a Patient with Severe Anaphylaxis/Metamizole Karsi IgE Aracili Reaksiyon: Agir Anafilaksili Bir Hastanin Degerlendirilmesi

Metamizole, a non-steroidal anti-inflammatory drug with weak anti-inflammatory and spasmolytic effects, is used as an analgesic and antipyretic agent. Many adverse reactions to metamizole, such as early or late-onset systemic reactions and bone marrow suppression, have been identified. In this repor...

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Veröffentlicht in:The Eurasian journal of medicine 2016-06, Vol.48 (2), p.145
Hauptverfasser: Arslan, Sevket, Ucar, Ramazan, Caliskaner, Ahmet Zafer
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Ucar, Ramazan
Caliskaner, Ahmet Zafer
description Metamizole, a non-steroidal anti-inflammatory drug with weak anti-inflammatory and spasmolytic effects, is used as an analgesic and antipyretic agent. Many adverse reactions to metamizole, such as early or late-onset systemic reactions and bone marrow suppression, have been identified. In this report, we present a case of systemic reaction after the application of parenteral metamizole (Novalgin[R] ampoule; Sanofi Aventis, Istanbul, Turkey) and discuss the mechanism underlying the reaction. Keywords: Abdominal pain, metamizole, systemic reactions Metamizol, temel olarak analjezik ve antipiretik etkili, ayrica kismen antiinflamatuvar ve spazmolitik etkileri de olan bir ilactir. Metamizole bagli bircok istenmeyen etki tanimlanmisti. Erken ya da gec baslangicli sistemik reaksiyonlara ve kemik iligi baskilanmasi ile iliskili reaksiyonlara neden olabilir. Bu makalede, parenteral metamizol (Novalgin[R] ampul; Sanofi aventis, Istanbul, Turkiye) uygulanmasini takiben sistemik reaksiyon gelisen bir hastada reaksiyonun mekanizmasina yonelik arastirmalar sunularak tartisilmaktadir. Anahtar Kelimeler: Karin agrisi, metamizol, sistemik reaksiyon
doi_str_mv 10.5152/eurasianjmed.2015.0024
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subjects Allergies
Analgesics
Antigens
Blood pressure
Bone marrow
Conflicts of interest
Drugs
Heart rate
Immunoglobulin E
Immunology
Mortality
Pain
Proteins
Skin
title IgE-Mediated Reaction to Metamizole: Evaluation of a Patient with Severe Anaphylaxis/Metamizole Karsi IgE Aracili Reaksiyon: Agir Anafilaksili Bir Hastanin Degerlendirilmesi
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