A Domino Ring-Closure Followed by Retro-Diels-Alder Reaction for the Preparation of Pyrimido[2,1-a]isoindole Enantiomers

A simple method was developed to prepare pyrimido[2,1‐a]isoindole derivatives by using di‐endo‐ and di‐exo‐ethyl 3‐aminobicyclo[2.2.1]hept‐5‐ene‐2‐carboxylate enantiomers as chiral sources. The method is based on a domino ring‐closure reaction of norbornene 2‐aminohydroxamic acid followed by microwa...

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Veröffentlicht in:	European journal of organic chemistry 2016-07, Vol.2016 (21), p.3519-3527
Hauptverfasser:	Fekete, Beáta, Palkó, Márta, Mándity, István, Haukka, Matti, Fülöp, Ferenc
Format:	Artikel
Sprache:	eng
Schlagworte:	Chiral resolution Domino reactions Microwave chemistry Nitrogen heterocycles Synthetic methods
Online-Zugang:	Volltext
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