Evaluation of Anti-inflammatory and Immunosuppressive Properties of Cynanchum ascyrifolium Matsum. and its Active Secondary Metabolites

Evaluation of Anti-inflammatory and Immunosuppressive Properties of Cynanchum ascyrifolium Matsum. and its Active Secondary Metabolites

The ethanol extract of Cynanchum ascyrifolium Matsum. showed significant anti-inflammatory and immunosuppressive activities with dose dependent manner using in vitro experiments. Then, the bioassay-guided ethanol extract lead to identification of four active compounds, namely ursolic acid (1), masli...

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Veröffentlicht in:Records of natural products 2016-01, Vol.10 (4), p.526
Hauptverfasser: Chao-Feng, Zhang, Liu, Xiu-Fen, Yan-Yan, Zhao, Zhang, Mian
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Acids
Bioassays
Drug dosages
Ethanol
Inflammation
Lymphocytes
Metabolites
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description The ethanol extract of Cynanchum ascyrifolium Matsum. showed significant anti-inflammatory and immunosuppressive activities with dose dependent manner using in vitro experiments. Then, the bioassay-guided ethanol extract lead to identification of four active compounds, namely ursolic acid (1), maslinic acid (2), cynanoside A (3) and syringaresinol (4). Among these compounds, cynanoside A (3), a C21 steroid, exhibited the highest anti-inflammatory and immunosuppressive effect on the Con-A or LPS activated lymphocytes at the concentration of 1 m M (P
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subjects Acids
Bioassays
Drug dosages
Ethanol
Inflammation
Lymphocytes
Metabolites
title Evaluation of Anti-inflammatory and Immunosuppressive Properties of Cynanchum ascyrifolium Matsum. and its Active Secondary Metabolites
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