Differential Effects of Sunitinib on the Expression Profiles of Xenobiotic‐Metabolizing Enzymes and Transporters in Rat Liver and Kidneys

Sunitinib (SUN) is a multi‐targeted tyrosine kinase inhibitor that was recently approved for the treatment of gastrointestinal tract and renal cancers. To date, very little is known about the effects of SUN on the expression of hepatic and renal xenobiotic‐metabolizing enzymes (XMEs) and transporter...

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Veröffentlicht in:	Basic & clinical pharmacology & toxicology 2016-08, Vol.119 (2), p.173-183
Hauptverfasser:	Korashy, Hesham M., Ansari, Mushtaq A., Maayah, Zaid H., Imam, Faisal, Raish, Mohammad, Attafi, Ibraheem M., Alharbi, Naif O., Moraished, Bader A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Aryl Hydrocarbon Hydroxylases - antagonists & inhibitors Aryl Hydrocarbon Hydroxylases - genetics Aryl Hydrocarbon Hydroxylases - metabolism ATP Binding Cassette Transporter, Sub-Family G, Member 2 - genetics ATP Binding Cassette Transporter, Sub-Family G, Member 2 - metabolism ATP-Binding Cassette Transporters - genetics ATP-Binding Cassette Transporters - metabolism Cytochrome P-450 CYP1A1 - genetics Cytochrome P-450 CYP1A1 - metabolism Cytochrome P-450 CYP1A2 - genetics Cytochrome P-450 CYP1A2 - metabolism Cytochrome P-450 CYP1B1 - genetics Cytochrome P-450 CYP1B1 - metabolism Cytochrome P-450 CYP2E1 - genetics Cytochrome P-450 CYP2E1 - metabolism Cytochrome P-450 Enzyme System - genetics Cytochrome P-450 Enzyme System - metabolism Cytochrome P450 Family 2 - antagonists & inhibitors Cytochrome P450 Family 2 - genetics Cytochrome P450 Family 2 - metabolism Cytochrome P450 Family 4 - genetics Cytochrome P450 Family 4 - metabolism Enzymes Glucuronosyltransferase - genetics Glucuronosyltransferase - metabolism Glutathione Transferase - genetics Glutathione Transferase - metabolism Indoles - pharmacology Isoenzymes - genetics Isoenzymes - metabolism Kidney - drug effects Kidney - enzymology Lipid Peroxidation - drug effects Liver - drug effects Liver - enzymology Male NAD(P)H Dehydrogenase (Quinone) - genetics NAD(P)H Dehydrogenase (Quinone) - metabolism Protein expression Proteins Pyrroles - pharmacology Rats Rats, Wistar RNA, Messenger - genetics RNA, Messenger - metabolism Rodents Steroid 16-alpha-Hydroxylase - antagonists & inhibitors Steroid 16-alpha-Hydroxylase - genetics Steroid 16-alpha-Hydroxylase - metabolism Transcriptome Xenobiotics - metabolism
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