Synthesis and characterization of related substances and metabolite of tadalafil, a PDE-5 inhibitor

Tadalafil (Cialis) is a potent and selective inhibitor of cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type-5 (PDE-5) and it is administered orally for the treatment of erectile dysfunction (ED). Two synthetic schemes were evaluated to study the impurity profile of tadalafil. Six...

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Veröffentlicht in:	Organic communications 2013-01, Vol.6 (1), p.12
Hauptverfasser:	Gilla, Goverdhan, Raghupathi Reddy Anumula, Sampath Aalla, Vurimidi, Himabindu, Mahesh Reddy Ghanta
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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