Structural and functional interactions between six-transmembrane [mu]-opioid receptors and [beta]2-adrenoreceptors modulate opioid signaling

The primary molecular target for clinically used opioids is the μ-opioid receptor (MOR). Besides the major seven-transmembrane (7TM) receptors, the MOR gene codes for alternatively spliced six-transmembrane (6TM) isoforms, the biological and clinical significance of which remains unclear. Here, we s...

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Veröffentlicht in:	Scientific reports 2015-12, Vol.5, p.18198
Hauptverfasser:	Samoshkin, Alexander, Convertino, Marino, Viet, Chi T, Wieskopf, Jeffrey S, Kambur, Oleg, Marcovitz, Jaclyn, Patel, Pinkal, Stone, Laura S, Kalso, Eija, Mogil, Jeffrey S, Schmidt, Brian L, Maixner, William, Dokholyan, Nikolay V, Diatchenko, Luda
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenergic receptors Alternative splicing Animal models Antagonists C cells Calcium Dorsal root ganglia Isoforms Narcotics Neuroblastoma Neuroblasts Opioid receptors (type mu) Pain perception Rodents Signal transduction Structure-function relationships
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