Ciprofloxacin blocked enterohepatic circulation of diclofenac and alleviated NSAID-induced enteropathy in rats partly by inhibiting intestinal [beta]-glucuronidase activity

Aim:Diclofenac is a non-steroidal anti-inflammatory drug (NSAID), which may cause serious intestinal adverse reactions (enteropathy). In this study we investigated whether co-administration of ciprofloxacin affected the pharmacokinetics of diclofenac and diclofenac-induced enteropathy in rats.Method...

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Veröffentlicht in:	Acta pharmacologica Sinica 2016-07, Vol.37 (7), p.1002
Hauptverfasser:	Zhong, Ze-yu, Sun, Bin-bin, Shu, Nan, Xie, Qiu-shi, Tang, Xian-ge, Ling, Zhao-li, Wang, Fan, Zhao, Kai-jing, Xu, Ping, Zhang, Mian, Li, Ying, Chen, Yang, Liu, Li, Xia, Lun-zhu, Liu, Xiao-dong
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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