The NF-[kappa]B subunit c-Rel regulates Bach2 tumour suppressor expression in B-cell lymphoma

The NF-[kappa]B subunit c-Rel regulates Bach2 tumour suppressor expression in B-cell lymphoma

The REL gene, encoding the NF-B subunit c-Rel, is frequently amplied in B-cell lymphoma and functions as a tumour-promoting transcription factor. Here we report the surprising result that c-rel/ mice display signicantly earlier lymphomagenesis in the c-Myc driven, E-Myc model of B-cell lymphoma. c-R...

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Veröffentlicht in:Oncogene 2016-06, Vol.35 (26), p.3476
Hauptverfasser: Hunter, J E, Butterworth, J A, Zhao, B, Sellier, H, Campbell, K J, Thomas, H D, Bacon, C M, Cockell, S J, Gewurz, B E, Perkins, N D
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Experiments
Genes
Lymphoma
Transcription factors
Tumors
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container_issue 26
container_start_page 3476
container_title Oncogene
container_volume 35
creator Hunter, J E
Butterworth, J A
Zhao, B
Sellier, H
Campbell, K J
Thomas, H D
Bacon, C M
Cockell, S J
Gewurz, B E
Perkins, N D
description The REL gene, encoding the NF-B subunit c-Rel, is frequently amplied in B-cell lymphoma and functions as a tumour-promoting transcription factor. Here we report the surprising result that c-rel/ mice display signicantly earlier lymphomagenesis in the c-Myc driven, E-Myc model of B-cell lymphoma. c-Rel loss also led to earlier onset of disease in a separate TCL1-Tg-driven lymphoma model. Tumour reimplantation experiments indicated that this is an effect intrinsic to the E-Myc lymphoma cells but, counterintuitively, c-rel/ E-Myc lymphoma cells were more sensitive to apoptotic stimuli.
doi_str_mv 10.1038/onc.2015.399
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subjects Experiments
Genes
Lymphoma
Transcription factors
Tumors
title The NF-[kappa]B subunit c-Rel regulates Bach2 tumour suppressor expression in B-cell lymphoma
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