The NF-[kappa]B subunit c-Rel regulates Bach2 tumour suppressor expression in B-cell lymphoma

The NF-[kappa]B subunit c-Rel regulates Bach2 tumour suppressor expression in B-cell lymphoma

The REL gene, encoding the NF-B subunit c-Rel, is frequently amplied in B-cell lymphoma and functions as a tumour-promoting transcription factor. Here we report the surprising result that c-rel/ mice display signicantly earlier lymphomagenesis in the c-Myc driven, E-Myc model of B-cell lymphoma. c-R...

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Veröffentlicht in:Oncogene 2016-06, Vol.35 (26), p.3476
Hauptverfasser: Hunter, J E, Butterworth, J A, Zhao, B, Sellier, H, Campbell, K J, Thomas, H D, Bacon, C M, Cockell, S J, Gewurz, B E, Perkins, N D
Format: Artikel
Sprache:eng
Schlagworte:
Experiments
Genes
Lymphoma
Transcription factors
Tumors
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Zusammenfassung:The REL gene, encoding the NF-B subunit c-Rel, is frequently amplied in B-cell lymphoma and functions as a tumour-promoting transcription factor. Here we report the surprising result that c-rel/ mice display signicantly earlier lymphomagenesis in the c-Myc driven, E-Myc model of B-cell lymphoma. c-Rel loss also led to earlier onset of disease in a separate TCL1-Tg-driven lymphoma model. Tumour reimplantation experiments indicated that this is an effect intrinsic to the E-Myc lymphoma cells but, counterintuitively, c-rel/ E-Myc lymphoma cells were more sensitive to apoptotic stimuli.
ISSN:0950-9232
1476-5594
DOI:10.1038/onc.2015.399