Selective spider toxins reveal a role for the Na^sub v^1.1 channel in mechanical pain

Voltage-gated sodium (Na^sub v^) channels initiate action potentials in most neurons, including primary afferent nerve fibres of the pain pathway. Local anaesthetics block pain through non-specific actions at all Na^sub v^ channels, but the discovery of selective modulators would facilitate the anal...

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Veröffentlicht in:	Nature (London) 2016-06, Vol.534 (7608), p.494
Hauptverfasser:	Osteen, Jeremiah D, Herzig, Volker, Gilchrist, John, Emrick, Joshua J, Zhang, Chuchu, Wang, Xidao, Castro, Joel, Garcia-Caraballo, Sonia, Grundy, Luke, Rychkov, Grigori Y, Weyer, Andy D, Dekan, Zoltan, Undheim, Eivind A B, Alewood, Paul, Stucky, Cheryl L, Brierley, Stuart M, Basbaum, Allan I, Bosmans, Frank, King, Glenn F, Julius, David
Format:	Artikel
Sprache:	eng
Schlagworte:	Fibers Hypersensitivity Migraine Mutation Neurons Pain Peptides Spiders Toxins Venom
Online-Zugang:	Volltext
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