Aminobenzimidazoles and Structural Isomers as Templates for Dual-Acting Butyrylcholinesterase Inhibitors and hCB2R Ligands To Combat Neurodegenerative Disorders

A pharmacophore model for butyrylcholinesterase (BChE) inhibitors was applied to a human cannabinoid subtype 2 receptor (hCB2R) agonist and verified it as a first‐generation lead for respective dual‐acting compounds. The design, synthesis, and pharmacological evaluation of various derivatives led to...

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Veröffentlicht in:	ChemMedChem 2016-06, Vol.11 (12), p.1270-1283
Hauptverfasser:	Dolles, Dominik, Nimczick, Martin, Scheiner, Matthias, Ramler, Jacqueline, Stadtmüller, Patricia, Sawatzky, Edgar, Drakopoulos, Antonios, Sotriffer, Christoph, Wittmann, Hans-Joachim, Strasser, Andrea, Decker, Michael
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer′s disease butyrylcholinesterase cannabinoid receptor ligands molecular dynamics multitarget compounds
Online-Zugang:	Volltext
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