NF-[kappa]B and androgen receptor variant 7 induce expression of SRD5A isoforms and confer 5ARI resistance

BACKGROUND Benign prostatic hyperplasia (BPH) is treated with 5[alpha]-reductase inhibitors (5ARI). These drugs inhibit the conversion of testosterone to dihydrotestosterone resulting in apoptosis and prostate shrinkage. Most patients initially respond to 5ARIs; however, failure is common especially...

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Veröffentlicht in:	The Prostate 2016-08, Vol.76 (11), p.1004
Hauptverfasser:	Austin, David C, Strand, Douglas W, Love, Harold L, Franco, Omar E, Grabowska, Magdalena M, Miller, Nicole L, Hameed, Omar, Clark, Peter E, Matusik, Robert J, Jin, Ren J, Hayward, Simon W
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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