Cytochrome P450 genetic variants and hypertension risk in South Indian population
Introduction: Hypertension is a result of interaction between complex environmental and genetic factors. The genes cytochrome (CYP) 2C8, CYP2C9, and CYP2J2 are involved in the metabolism of arachidonic acid, which releases endothelium derived hyperpolarizing factors responsible for mediating the smo...
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| Veröffentlicht in: | Journal of young pharmacists 2014-01, Vol.6 (1), p.22-26 |
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| creator | Arun Kumar, Annan Sudarsan Suresh Kumar, Srinivasamurthy Umamaheswaran, Gurusamy Balachandar, Jayaraman Adithan, Chandrasekaran |
| description | Introduction: Hypertension is a result of interaction between complex environmental and genetic factors. The genes cytochrome (CYP) 2C8, CYP2C9, and CYP2J2 are involved in the metabolism of arachidonic acid, which releases endothelium derived hyperpolarizing factors responsible for mediating the smooth muscle relaxation. Aim: The study is aimed to analyze the association of CYP2C8, CYP2C9, and CYP2J2 gene polymorphisms with the risk of hypertension in the South Indian population. Methods and Results: The case-control study consisted of 279 hypertensive patients and 321 healthy controls aged ranges between 30 and 60 years. The deoxyribonucleic acid was extracted using standard phenol-chloroform method. Genotyping was performed by polymerase chain reaction (PCR)-restriction fragment length polymorphism and real-time-PCR methods. Multiple-logistic regression analysis was used to analyze the association between polymorphisms and the risk of hypertension. We did not observe any association of CYP2C8*2, CYP2C8*3, CYP2C9*2, CYP2C9*3, and CYP2J2*7 with hypertension. Conclusion: Our results suggest that CYP2C8*2, CYP2C8*3, CYP2C9*2, CYP2C9*3, and CYP2J2*7 are not associated with hypertension in South Indian population. |
| doi_str_mv | 10.5530/jyp.2014.1.4 |
| format | Article |
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The genes cytochrome (CYP) 2C8, CYP2C9, and CYP2J2 are involved in the metabolism of arachidonic acid, which releases endothelium derived hyperpolarizing factors responsible for mediating the smooth muscle relaxation. Aim: The study is aimed to analyze the association of CYP2C8, CYP2C9, and CYP2J2 gene polymorphisms with the risk of hypertension in the South Indian population. Methods and Results: The case-control study consisted of 279 hypertensive patients and 321 healthy controls aged ranges between 30 and 60 years. The deoxyribonucleic acid was extracted using standard phenol-chloroform method. Genotyping was performed by polymerase chain reaction (PCR)-restriction fragment length polymorphism and real-time-PCR methods. Multiple-logistic regression analysis was used to analyze the association between polymorphisms and the risk of hypertension. We did not observe any association of CYP2C8*2, CYP2C8*3, CYP2C9*2, CYP2C9*3, and CYP2J2*7 with hypertension. Conclusion: Our results suggest that CYP2C8*2, CYP2C8*3, CYP2C9*2, CYP2C9*3, and CYP2J2*7 are not associated with hypertension in South Indian population.</description><identifier>ISSN: 0975-1483</identifier><identifier>EISSN: 0975-1505</identifier><identifier>DOI: 10.5530/jyp.2014.1.4</identifier><language>eng</language><publisher>Bangalore: InPharm</publisher><subject>Genotype & phenotype ; Hypertension ; Minority & ethnic groups ; Population genetics ; Risk factors</subject><ispartof>Journal of young pharmacists, 2014-01, Vol.6 (1), p.22-26</ispartof><rights>Copyright InPharm Jan-Mar 2014</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids></links><search><creatorcontrib>Arun Kumar, Annan Sudarsan</creatorcontrib><creatorcontrib>Suresh Kumar, Srinivasamurthy</creatorcontrib><creatorcontrib>Umamaheswaran, Gurusamy</creatorcontrib><creatorcontrib>Balachandar, Jayaraman</creatorcontrib><creatorcontrib>Adithan, Chandrasekaran</creatorcontrib><title>Cytochrome P450 genetic variants and hypertension risk in South Indian population</title><title>Journal of young pharmacists</title><description>Introduction: Hypertension is a result of interaction between complex environmental and genetic factors. The genes cytochrome (CYP) 2C8, CYP2C9, and CYP2J2 are involved in the metabolism of arachidonic acid, which releases endothelium derived hyperpolarizing factors responsible for mediating the smooth muscle relaxation. Aim: The study is aimed to analyze the association of CYP2C8, CYP2C9, and CYP2J2 gene polymorphisms with the risk of hypertension in the South Indian population. Methods and Results: The case-control study consisted of 279 hypertensive patients and 321 healthy controls aged ranges between 30 and 60 years. The deoxyribonucleic acid was extracted using standard phenol-chloroform method. Genotyping was performed by polymerase chain reaction (PCR)-restriction fragment length polymorphism and real-time-PCR methods. Multiple-logistic regression analysis was used to analyze the association between polymorphisms and the risk of hypertension. We did not observe any association of CYP2C8*2, CYP2C8*3, CYP2C9*2, CYP2C9*3, and CYP2J2*7 with hypertension. Conclusion: Our results suggest that CYP2C8*2, CYP2C8*3, CYP2C9*2, CYP2C9*3, and CYP2J2*7 are not associated with hypertension in South Indian population.</description><subject>Genotype & phenotype</subject><subject>Hypertension</subject><subject>Minority & ethnic groups</subject><subject>Population genetics</subject><subject>Risk factors</subject><issn>0975-1483</issn><issn>0975-1505</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNo1kMFKAzEQhoMoWGpvPkDAq7smmaTZHKWoLRRU1HNIs1m7tU3WJCvs27ulOpcZmI__hw-ha0pKIYDc7YauZITykpb8DE2IkqKggojz_5tXcIlmKe3IcSSRoCbodTHkYLcxHBx-4YLgT-ddbi3-MbE1PidsfI23Q-didj61wePYpi_cevwW-rzFK1-PHO5C1-9NHv9X6KIx--Rmf3uKPh4f3hfLYv38tFrcrwvLFMmFkWzuXO3UvJbMwoaBsKyi1DnDGrupAKRoNqCIomauLBNMOF4ZxaCWpqkBpujmlNvF8N27lPUu9NGPlZpKJYFIDmKkbk-UjSGl6BrdxfZg4qAp0UdvevSmj9401Rx-Aav4YI0</recordid><startdate>20140101</startdate><enddate>20140101</enddate><creator>Arun Kumar, Annan Sudarsan</creator><creator>Suresh Kumar, Srinivasamurthy</creator><creator>Umamaheswaran, Gurusamy</creator><creator>Balachandar, Jayaraman</creator><creator>Adithan, Chandrasekaran</creator><general>InPharm</general><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>KB0</scope><scope>M2O</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope></search><sort><creationdate>20140101</creationdate><title>Cytochrome P450 genetic variants and hypertension risk in South Indian population</title><author>Arun Kumar, Annan Sudarsan ; Suresh Kumar, Srinivasamurthy ; Umamaheswaran, Gurusamy ; Balachandar, Jayaraman ; Adithan, Chandrasekaran</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c290t-a726eede96d72c3b235c2811eea2fcb83375fb39091a69c2525e48a923d7afd33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Genotype & phenotype</topic><topic>Hypertension</topic><topic>Minority & ethnic groups</topic><topic>Population genetics</topic><topic>Risk factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Arun Kumar, Annan Sudarsan</creatorcontrib><creatorcontrib>Suresh Kumar, Srinivasamurthy</creatorcontrib><creatorcontrib>Umamaheswaran, Gurusamy</creatorcontrib><creatorcontrib>Balachandar, Jayaraman</creatorcontrib><creatorcontrib>Adithan, Chandrasekaran</creatorcontrib><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><jtitle>Journal of young pharmacists</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Arun Kumar, Annan Sudarsan</au><au>Suresh Kumar, Srinivasamurthy</au><au>Umamaheswaran, Gurusamy</au><au>Balachandar, Jayaraman</au><au>Adithan, Chandrasekaran</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cytochrome P450 genetic variants and hypertension risk in South Indian population</atitle><jtitle>Journal of young pharmacists</jtitle><date>2014-01-01</date><risdate>2014</risdate><volume>6</volume><issue>1</issue><spage>22</spage><epage>26</epage><pages>22-26</pages><issn>0975-1483</issn><eissn>0975-1505</eissn><abstract>Introduction: Hypertension is a result of interaction between complex environmental and genetic factors. The genes cytochrome (CYP) 2C8, CYP2C9, and CYP2J2 are involved in the metabolism of arachidonic acid, which releases endothelium derived hyperpolarizing factors responsible for mediating the smooth muscle relaxation. Aim: The study is aimed to analyze the association of CYP2C8, CYP2C9, and CYP2J2 gene polymorphisms with the risk of hypertension in the South Indian population. Methods and Results: The case-control study consisted of 279 hypertensive patients and 321 healthy controls aged ranges between 30 and 60 years. The deoxyribonucleic acid was extracted using standard phenol-chloroform method. Genotyping was performed by polymerase chain reaction (PCR)-restriction fragment length polymorphism and real-time-PCR methods. Multiple-logistic regression analysis was used to analyze the association between polymorphisms and the risk of hypertension. We did not observe any association of CYP2C8*2, CYP2C8*3, CYP2C9*2, CYP2C9*3, and CYP2J2*7 with hypertension. Conclusion: Our results suggest that CYP2C8*2, CYP2C8*3, CYP2C9*2, CYP2C9*3, and CYP2J2*7 are not associated with hypertension in South Indian population.</abstract><cop>Bangalore</cop><pub>InPharm</pub><doi>10.5530/jyp.2014.1.4</doi><tpages>5</tpages></addata></record> |
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| subjects | Genotype & phenotype Hypertension Minority & ethnic groups Population genetics Risk factors |
| title | Cytochrome P450 genetic variants and hypertension risk in South Indian population |
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