Role of IL-4 receptor [alpha]-positive CD4+T cells in chronic airway hyperresponsiveness

Background TH2 cells and their cytokines are associated with allergic asthma in human subjects and with mouse models of allergic airway disease. IL-4 signaling through the IL-4 receptor α (IL-4Rα) chain on CD4+T cells leads to TH2 cell differentiationin vitro, implying that IL-4Rα-responsive CD4+T c...

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Veröffentlicht in:	Journal of allergy and clinical immunology 2016-06, Vol.137 (6), p.1852
Hauptverfasser:	Kirstein, Frank, Nieuwenhuizen, Natalie E, Jayakumar, Jaisubash, Horsnell, William GC, Brombacher, Frank
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergies Asthma Chlorophyll Cytokines Experiments Lungs Lymphocytes Neutrophils Pathogenesis Pathology Proteins Rodents Software
Online-Zugang:	Volltext
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