674. Molecular, Biochemical and Biomechanical Analysis of Articular Cartilage Repaired with Genetically Modified Chondrocytes Expressing Insulin-Like Growth Factor-I

Insulin-like growth factor-I (IGF-I) has been shown to be important for normal articular chondrocyte function. Gene therapy offers the prospect of extending the time IGF-I is released in cartilage injury. The purpose of this study was to investigate the molecular, biochemical and biomechanical effec...

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