846. Copolymer-Protected Vector Mediated BMP-2 Gene Delivery to Articular Chondrocytes in a 3-Dimensional Injectable Fibrin Matrix for Tissue Engineering

We have previously demonstrated the superiority of copolymer-protected gene vectors (COPROGs) over naked DNA and standard nonviral vectors in matrix-mediated gene delivery (Scherer et al. 2002, J. Gene Med. 4:634-643). Here we present a novel carrier formulation based on lyophilized fibrinogen-vecto...

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Veröffentlicht in:	Molecular therapy 2004-05, Vol.9 (S1), p.S321
Hauptverfasser:	Schillinger, Ulrike, Wexel, Gabi, Hacker, Christian, Kullmer, Martin, Stemberger, Axel, Plank, Christian
Format:	Artikel
Sprache:	eng
Schlagworte:	Androgens Cancer therapies Cartilage Extracellular matrix Gene expression Gene therapy Growth factors Kinases Phosphatase Prostate cancer Radiation therapy Signal transduction Tissue engineering Tumors Vectors (Biology)
Online-Zugang:	Volltext
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