527. CERE-110, an AAV2-Based Vector To Deliver NGF, Provides Trophic Activity to Basal Forebrain Cholinergic Neurons in Rats and Cynomolgous Monkeys

Numerous studies indicate that providing trophic support to degenerating basal forebrain cholinergic neurons with nerve growth factor (NGF) is a logical approach to treating mild to moderate Alzheimer's disease. However, since NGF does not effectively reach basal forebrain cholinergic neurons w...

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Veröffentlicht in:	Molecular therapy 2004-05, Vol.9 (S1), p.S199-S200
Hauptverfasser:	Bishop, Kathie M, Hofer, Katrin, Rius, Denise, Mehta, Arpesh, Lawandry, Shokry, Brown, Lamar, Kruegel, Brian, Gasmi, Mehdi, Tuszynski, Mark, Bartus, Raymond T
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer's disease Amyloidosis Amyotrophic lateral sclerosis Bone marrow Disease Enzymes Gene therapy Mutation Nervous system Neurodegeneration Neurons Neurosciences Pathology Transplants & implants
Online-Zugang:	Volltext
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