752. Effect of 127 Mutations at 72 Positions on the Surface of Adeno-Associated Virus Type-2

Our goal is to identify mutations on the external surface of AAV-2 capsid that reduce neutralization by antibodies, but have minimal effects on biological properties. 127 mutations were made at 72 positions (55 % of surface area) deemed most likely to be accessible to antibody binding based on manua...

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Veröffentlicht in:	Molecular therapy 2004-05, Vol.9 (S1), p.S286-S286
Hauptverfasser:	Lochrie, Michael, Tatsuno, Gwen, Wellman, Jennifer, Zhou, Shang-zhen, Surosky, Richard, Pierce, Glenn, Colosi, Peter
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino acids Antibodies Binding sites Mutation Viruses
Online-Zugang:	Volltext
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