Optimization of Nonviral Gene Transfer of Vascular Smooth Muscle Cells in Vitro and in Vivo

Gene therapy strategies for the prevention of restenosis postangioplasty are promising. Nonviral gene transfer to the arterial wall in vivo has so far been limited by poor efficiency. This study aimed to optimize transfection of primary vascular smooth muscle cells using cationic nonviral formulatio...

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Veröffentlicht in:	Molecular therapy 2000-04, Vol.1 (4), p.366-375
Hauptverfasser:	Armeanu, Sorin, Pelisek, Jaroslav, Krausz, Eberhard, Fuchs, Alexandra, Groth, Detlef, Curth, Rene, Keil, Oliver, Quilici, Jacques, Rolland, Pierre H., Reszka, Regina, Nikol, Sigrid
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoviruses Angioplasty Animals Base Sequence beta-Galactosidase - genetics beta-Galactosidase - metabolism Catheters Cell cycle Cell growth Cholesterol DNA Primers - genetics Gene Expression Gene therapy gene transfer Gene Transfer Techniques Genes, Reporter Genetic Therapy Humans In Vitro Techniques Lipids Liposomes local drug delivery Muscle, Smooth, Vascular - cytology Muscle, Smooth, Vascular - metabolism Optimization Plasmids Plasmids - administration & dosage Plasmids - genetics Reagents Smooth muscle Swine Toxicity Transfection vascular smooth muscle cells Vectors (Biology) Veins & arteries
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