Blockade of TNF-[alpha] Decreases Both Inflammation and Efficacy of Intrapulmonary Ad.IFN[beta] Immunotherapy in an Orthotopic Model of Bronchogenic Lung Cancer

Adenoviral immuno-gene therapy using interferon-β has been effective in an orthotopic model of lung cancer. However, pulmonary inflammation induced by adenoviral (Ad) vectors will almost certainly limit the maximally tolerated dose. On the other hand, the strong innate immune response generated by t...

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Veröffentlicht in:	Molecular therapy 2006-05, Vol.13 (5), p.910
Hauptverfasser:	Wilderman, Michael J, Kim, Samuel, Gillespie, Collin T, Sun, Jing, Kapoor, Veena, Vachani, Anil, Sterman, Daniel H, Kaiser, Larry R, Albelda, Steven M
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoviruses Animals Antibodies Cancer therapies Clinical trials Cytokines Gene therapy Immunotherapy Inflammation Interferon Lung cancer Lung diseases Mesothelioma Metastasis Neutrophils Oncology Toxicity Tumor necrosis factor-TNF Tumors Vectors (Biology)
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