115. Whole Genome Analysis Shows That AAV Integrates at Chromosome 19 AAV-S1 Sites and Other Chromosomal Sites That Frequently Share GGTC Micro-Homology with the AAV P5 Promoter

Adeno associated virus undergoes Rep-mediated integration into the AAV-S1 region of human chromosome 19 during latent infection but recombinant AAV (rAAV) vectors are missing essential viral components and lack such site-specificity. This was best shown recently by strategies that monitor rAAV integ...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Molecular therapy 2006-05, Vol.13 (S1), p.S47
Hauptverfasser:	Drew, Horace R., Lockett, Linda J., Both, Gerald W.
Format:	Artikel
Sprache:	eng
Schlagworte:	Chromosomes Cloning Gene therapy Genomes Infections Kinases Liver Medicine Vectors (Biology)
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!