700. Formulation of Chemically Modified Short Interfering RNA (siRNA) for Local Delivery to the Respiratory Tract

RNA interference using synthetic siRNAs to inhibit gene expression in a sequence-specific manner offers a novel opportunity for treating pulmonary diseases including asthma, airway inflammation, and respiratory viral infections. Developing siRNAs as therapeutics will however require chemical modific...

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Veröffentlicht in:	Molecular therapy 2006-05, Vol.13 (S1), p.S271
Hauptverfasser:	McCray, Paul B., Dickinson, Brent A., Hartsough, Kim C., Gomez, Anna M., Jamison, Sharon F., Shadel, Tim R., Lockridge, Jennifer A., Pavco, Pam A., Wang, Wei-min, Chen, Tongqian, Vargeese, Chandra, Tung, David K., Wohlford-Lenane, Christine L., Richards, Ivan M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aerosols Bacteria Drug dosages E coli Gene expression Gene therapy Lungs Pediatrics Proteins
Online-Zugang:	Volltext
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