777. A Novel Pan-Oncolytic Adenovirus Therapeutically Effective in Different Cancer Cell Types

SPARC is a matricellular protein that is overexpressed in malignant and stromal components of human melanomas. We have previously shown that a 1.3 Kb SPARC promoter region was effective in driving suicide gene expression both in melanoma and endothelial cells leading to the elimination of melanoma t...

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