Physiological Promoters Reduce the Genotoxic Risk of Integrating Gene Vectors

The possible activation of cellular proto-oncogenes as a result of clonal transformation is a potential limitation in a therapeutic approach involving random integration of gene vectors. Given that enhancer promiscuity represents an important mechanism of insertional transformation, we assessed the...

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Veröffentlicht in:	Molecular therapy 2008-04, Vol.16 (4), p.718-725
Hauptverfasser:	Zychlinski, Daniela, Schambach, Axel, Modlich, Ute, Maetzig, Tobias, Meyer, Johann, Grassman, Elke, Mishra, Anjali, Baum, Christopher
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Binding sites Bone Marrow Cells - metabolism Cell Line Cells, Cultured Cytomegalovirus Design DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Enhancer Elements, Genetic Fibroblasts - metabolism Gene therapy Genetic Vectors - toxicity Genomes Hematology Humans Kinases MDS1 and EVI1 Complex Locus Protein Mice Mice, Inbred C57BL Mutagenesis, Insertional Peptide Elongation Factor 1 - genetics Peptide Elongation Factor 1 - metabolism Phosphoglycerate Kinase - genetics Phosphoglycerate Kinase - metabolism Physiology Promoter Regions, Genetic Proto-Oncogenes - genetics Retroviridae - genetics Transcription Factors - genetics Transcription Factors - metabolism Transfection - methods Vectors (Biology)
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