Efficient Generation of Functional Hepatocytes From Human Embryonic Stem Cells and Induced Pluripotent Stem Cells by HNF4[alpha] Transduction

Hepatocyte-like cells from human embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) are expected to be a useful source of cells drug discovery. Although we recently reported that hepatic commitment is promoted by transduction of SOX17 and HEX into human ESC- and iPSC-derived cell...

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Veröffentlicht in:	Molecular therapy 2012-01, Vol.20 (1), p.127
Hauptverfasser:	Takayama, Kazuo, Inamura, Mitsuru, Kawabata, Kenji, Katayama, Kazufumi, Higuchi, Maiko, Tashiro, Katsuhisa, Nonaka, Aki, Sakurai, Fuminori, Hayakawa, Takao, Kusuda Furue, Miho, Mizuguchi, Hiroyuki
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoviruses Biochemistry Cytochrome Enzymes Gene expression Liver Molecular biology Pancreas Pharmaceutical sciences R&D Research & development Stem cells Toxicity Transcription factors
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