MicroRNA-223 controls the expression of histone deacetylase 2: a novel axis in COPD

Reduced activity of histone deacetylase 2 (HDAC2) has been described in patients with chronic obstructive pulmonary disease (COPD), but the mechanisms resulting in decreased expression of this important epigenetic modifier remain unknown. Here, we employed several in vitro experiments to address the...

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Veröffentlicht in:	Journal of molecular medicine (Berlin, Germany) Germany), 2016-06, Vol.94 (6), p.725-734
Hauptverfasser:	Leuenberger, Caroline, Schuoler, Claudio, Bye, Hannah, Mignan, Célia, Rechsteiner, Thomas, Hillinger, Sven, Opitz, Isabelle, Marsland, Benjamin, Faiz, Alen, Hiemstra, Pieter S., Timens, Wim, Camici, Giovanni G., Kohler, Malcolm, Huber, Lars C., Brock, Matthias
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Base Sequence Biomedical and Life Sciences Biomedicine Cell Line Chemokine CX3CL1 - genetics Chemokine CX3CL1 - metabolism Complex Mixtures - toxicity Disease Models, Animal Endothelial Cells - cytology Endothelial Cells - drug effects Endothelial Cells - metabolism Epigenesis, Genetic Histone Deacetylase 2 - genetics Histone Deacetylase 2 - metabolism Human Genetics Humans Interleukin-1 - pharmacology Internal Medicine Lipopolysaccharides - pharmacology Mice MicroRNAs - antagonists & inhibitors MicroRNAs - genetics MicroRNAs - metabolism Molecular Medicine Nicotiana - chemistry Nicotiana - toxicity Oligoribonucleotides, Antisense - genetics Oligoribonucleotides, Antisense - metabolism Original Article Pulmonary Artery - cytology Pulmonary Artery - drug effects Pulmonary Artery - metabolism Pulmonary Disease, Chronic Obstructive - genetics Pulmonary Disease, Chronic Obstructive - metabolism Pulmonary Disease, Chronic Obstructive - pathology Pulmonary Emphysema - chemically induced Pulmonary Emphysema - genetics Pulmonary Emphysema - metabolism Pulmonary Emphysema - pathology Signal Transduction Smoke - adverse effects Tumor Necrosis Factor-alpha - pharmacology
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