Assessment of left ventricular ejection fraction using low radiation dose computed tomography
Cardiac CT is a non-invasive modality with the ability to estimate LVEF. However, given its limited temporal resolution and radiation, there has been initial resistance to use CT to measure LVEF. Developing an accurate, fast, low radiation dose protocol is desirable. The objective of this study is t...
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| Veröffentlicht in: | Journal of nuclear cardiology 2016-06, Vol.23 (3), p.414-421 |
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| creator | Yang, YiQi Yam, Yeung Chen, Li Aljizeeri, Ahmed Aliyary Ghraboghly, Siamak Al-Harbi, Ibraheem Pen, Ally Ruddy, Terrence D. Chow, Benjamin J.W. |
| description | Cardiac CT is a non-invasive modality with the ability to estimate LVEF. However, given its limited temporal resolution and radiation, there has been initial resistance to use CT to measure LVEF. Developing an accurate, fast, low radiation dose protocol is desirable.
The objective of this study is to demonstrate that a ‘low radiation dose’ 64 slice cardiac computed tomography (CT) protocol is feasible and can accurately measure left ventricular ejection fraction (LVEF) while delivering a radiation dose lower than radionuclide angiography (RNA).
Patients undergoing RNA were prospectively screened and enrolled to undergo a ‘low-dose’ 64 slice CT LVEF protocol. LVEF measures, duration of each study and radiation dose between CT and RNA were compared.
A total of 77 patients (mean age = 61.8 ± 12.2 years and 58 men) were analyzed. The mean LVEF measured by CT and RNA were 41.9 ± 15.2% and 39.4 ± 13.9%, respectively, (P = 0.154) with a good correlation (r = 0.863). Bland-Altman plot revealed a good agreement between the CT and RNA LVEF (mean difference of −2.4). There was good agreement between CT LVEF and RNA for identifying patients with LVEF ≤30% (kappa = 0.693) and LVEF ≥50% (kappa = 0.749). The mean dose estimated effective dose for CT and RNA were 4.7 ± 1.6 and 9.5 ± 1.0 mSv, respectively. The mean CT LVEF imaging duration (4:32 ± 3:05 minutes) was significantly shorter than the RNA image acquisition time (9:05 ± 2:36 minutes; p < 0.001).
The results of our study suggest that low-dose CT LVEF protocol is feasible, accurate, and fast while delivering a lower radiation dose than traditional RNA. |
| doi_str_mv | 10.1007/s12350-015-0123-6 |
| format | Article |
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The objective of this study is to demonstrate that a ‘low radiation dose’ 64 slice cardiac computed tomography (CT) protocol is feasible and can accurately measure left ventricular ejection fraction (LVEF) while delivering a radiation dose lower than radionuclide angiography (RNA).
Patients undergoing RNA were prospectively screened and enrolled to undergo a ‘low-dose’ 64 slice CT LVEF protocol. LVEF measures, duration of each study and radiation dose between CT and RNA were compared.
A total of 77 patients (mean age = 61.8 ± 12.2 years and 58 men) were analyzed. The mean LVEF measured by CT and RNA were 41.9 ± 15.2% and 39.4 ± 13.9%, respectively, (P = 0.154) with a good correlation (r = 0.863). Bland-Altman plot revealed a good agreement between the CT and RNA LVEF (mean difference of −2.4). There was good agreement between CT LVEF and RNA for identifying patients with LVEF ≤30% (kappa = 0.693) and LVEF ≥50% (kappa = 0.749). The mean dose estimated effective dose for CT and RNA were 4.7 ± 1.6 and 9.5 ± 1.0 mSv, respectively. The mean CT LVEF imaging duration (4:32 ± 3:05 minutes) was significantly shorter than the RNA image acquisition time (9:05 ± 2:36 minutes; p < 0.001).
The results of our study suggest that low-dose CT LVEF protocol is feasible, accurate, and fast while delivering a lower radiation dose than traditional RNA.</description><identifier>ISSN: 1071-3581</identifier><identifier>EISSN: 1532-6551</identifier><identifier>DOI: 10.1007/s12350-015-0123-6</identifier><identifier>PMID: 26002814</identifier><language>eng</language><publisher>New York: Elsevier Inc</publisher><subject>Cardiology ; Computed tomography ; ejection fraction ; Feasibility Studies ; Female ; Humans ; Imaging ; Male ; Medicine ; Medicine & Public Health ; Middle Aged ; Nuclear Medicine ; Original Article ; Radiation Dosage ; Radiation Protection - methods ; Radiographic Image Enhancement - methods ; Radiographic Image Interpretation, Computer-Assisted - methods ; Radiology ; radionuclide angiography ; Radionuclide Angiography - methods ; Reproducibility of Results ; Sensitivity and Specificity ; Stroke Volume ; Tomography, X-Ray Computed - methods ; Ventricular Dysfunction, Left - diagnostic imaging</subject><ispartof>Journal of nuclear cardiology, 2016-06, Vol.23 (3), p.414-421</ispartof><rights>2016 American Society of Nuclear Cardiology. Published by ELSEVIER INC. All rights reserved.</rights><rights>American Society of Nuclear Cardiology 2015</rights><rights>American Society of Nuclear Cardiology 2016</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c424t-c34e5b147f5a537a4c015cc6d4511e0e28f1f73f77e9b1c1a752122aad95c973</citedby><cites>FETCH-LOGICAL-c424t-c34e5b147f5a537a4c015cc6d4511e0e28f1f73f77e9b1c1a752122aad95c973</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s12350-015-0123-6$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s12350-015-0123-6$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27922,27923,41486,42555,51317</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26002814$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yang, YiQi</creatorcontrib><creatorcontrib>Yam, Yeung</creatorcontrib><creatorcontrib>Chen, Li</creatorcontrib><creatorcontrib>Aljizeeri, Ahmed</creatorcontrib><creatorcontrib>Aliyary Ghraboghly, Siamak</creatorcontrib><creatorcontrib>Al-Harbi, Ibraheem</creatorcontrib><creatorcontrib>Pen, Ally</creatorcontrib><creatorcontrib>Ruddy, Terrence D.</creatorcontrib><creatorcontrib>Chow, Benjamin J.W.</creatorcontrib><title>Assessment of left ventricular ejection fraction using low radiation dose computed tomography</title><title>Journal of nuclear cardiology</title><addtitle>J. Nucl. Cardiol</addtitle><addtitle>J Nucl Cardiol</addtitle><description>Cardiac CT is a non-invasive modality with the ability to estimate LVEF. However, given its limited temporal resolution and radiation, there has been initial resistance to use CT to measure LVEF. Developing an accurate, fast, low radiation dose protocol is desirable.
The objective of this study is to demonstrate that a ‘low radiation dose’ 64 slice cardiac computed tomography (CT) protocol is feasible and can accurately measure left ventricular ejection fraction (LVEF) while delivering a radiation dose lower than radionuclide angiography (RNA).
Patients undergoing RNA were prospectively screened and enrolled to undergo a ‘low-dose’ 64 slice CT LVEF protocol. LVEF measures, duration of each study and radiation dose between CT and RNA were compared.
A total of 77 patients (mean age = 61.8 ± 12.2 years and 58 men) were analyzed. The mean LVEF measured by CT and RNA were 41.9 ± 15.2% and 39.4 ± 13.9%, respectively, (P = 0.154) with a good correlation (r = 0.863). Bland-Altman plot revealed a good agreement between the CT and RNA LVEF (mean difference of −2.4). There was good agreement between CT LVEF and RNA for identifying patients with LVEF ≤30% (kappa = 0.693) and LVEF ≥50% (kappa = 0.749). The mean dose estimated effective dose for CT and RNA were 4.7 ± 1.6 and 9.5 ± 1.0 mSv, respectively. The mean CT LVEF imaging duration (4:32 ± 3:05 minutes) was significantly shorter than the RNA image acquisition time (9:05 ± 2:36 minutes; p < 0.001).
The results of our study suggest that low-dose CT LVEF protocol is feasible, accurate, and fast while delivering a lower radiation dose than traditional RNA.</description><subject>Cardiology</subject><subject>Computed tomography</subject><subject>ejection fraction</subject><subject>Feasibility Studies</subject><subject>Female</subject><subject>Humans</subject><subject>Imaging</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Nuclear Medicine</subject><subject>Original Article</subject><subject>Radiation Dosage</subject><subject>Radiation Protection - methods</subject><subject>Radiographic Image Enhancement - methods</subject><subject>Radiographic Image Interpretation, Computer-Assisted - methods</subject><subject>Radiology</subject><subject>radionuclide angiography</subject><subject>Radionuclide Angiography - methods</subject><subject>Reproducibility of Results</subject><subject>Sensitivity and Specificity</subject><subject>Stroke Volume</subject><subject>Tomography, X-Ray Computed - methods</subject><subject>Ventricular Dysfunction, Left - diagnostic imaging</subject><issn>1071-3581</issn><issn>1532-6551</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp9kMtOxCAUhonReH8AN4bEdZUDpbRxZYy3xMSNW0MYehiZTMsIrWbeXsaqceWCcID_Ej5CToCdA2PqIgEXkhUMZF5cFNUW2QcpeFFJCdt5ZgoKIWvYIwcpLRhjjWiaXbLHK8Z4DeU-eblKCVPqsB9ocHSJbqDv-RC9HZcmUlygHXzoqYtmGsbk-zldhg8aTevN110bElIbutU4YEuH0IV5NKvX9RHZcWaZ8Ph7PyTPtzfP1_fF49Pdw_XVY2FLXg6FFSXKGZTKSSOFMqXNX7K2aksJgAx57cAp4ZTCZgYWjJIcODembaRtlDgkZ1PsKoa3EdOgF2GMfW7UoOq6aupSVFkFk8rGkFJEp1fRdyauNTC94aknnjqX6w1PvfGcfiePsw7bX8cPwCzgkyDlp36O8U_1P6mXkwkzk3efTcl67C22Pmbcug3-H_cnAC6UTg</recordid><startdate>20160601</startdate><enddate>20160601</enddate><creator>Yang, YiQi</creator><creator>Yam, Yeung</creator><creator>Chen, Li</creator><creator>Aljizeeri, Ahmed</creator><creator>Aliyary Ghraboghly, Siamak</creator><creator>Al-Harbi, Ibraheem</creator><creator>Pen, Ally</creator><creator>Ruddy, Terrence D.</creator><creator>Chow, Benjamin J.W.</creator><general>Elsevier Inc</general><general>Springer US</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope></search><sort><creationdate>20160601</creationdate><title>Assessment of left ventricular ejection fraction using low radiation dose computed tomography</title><author>Yang, YiQi ; Yam, Yeung ; Chen, Li ; Aljizeeri, Ahmed ; Aliyary Ghraboghly, Siamak ; Al-Harbi, Ibraheem ; Pen, Ally ; Ruddy, Terrence D. ; Chow, Benjamin J.W.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c424t-c34e5b147f5a537a4c015cc6d4511e0e28f1f73f77e9b1c1a752122aad95c973</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Cardiology</topic><topic>Computed tomography</topic><topic>ejection fraction</topic><topic>Feasibility Studies</topic><topic>Female</topic><topic>Humans</topic><topic>Imaging</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Nuclear Medicine</topic><topic>Original Article</topic><topic>Radiation Dosage</topic><topic>Radiation Protection - methods</topic><topic>Radiographic Image Enhancement - methods</topic><topic>Radiographic Image Interpretation, Computer-Assisted - methods</topic><topic>Radiology</topic><topic>radionuclide angiography</topic><topic>Radionuclide Angiography - methods</topic><topic>Reproducibility of Results</topic><topic>Sensitivity and Specificity</topic><topic>Stroke Volume</topic><topic>Tomography, X-Ray Computed - methods</topic><topic>Ventricular Dysfunction, Left - diagnostic imaging</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yang, YiQi</creatorcontrib><creatorcontrib>Yam, Yeung</creatorcontrib><creatorcontrib>Chen, Li</creatorcontrib><creatorcontrib>Aljizeeri, Ahmed</creatorcontrib><creatorcontrib>Aliyary Ghraboghly, Siamak</creatorcontrib><creatorcontrib>Al-Harbi, Ibraheem</creatorcontrib><creatorcontrib>Pen, Ally</creatorcontrib><creatorcontrib>Ruddy, Terrence D.</creatorcontrib><creatorcontrib>Chow, Benjamin J.W.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><jtitle>Journal of nuclear cardiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yang, YiQi</au><au>Yam, Yeung</au><au>Chen, Li</au><au>Aljizeeri, Ahmed</au><au>Aliyary Ghraboghly, Siamak</au><au>Al-Harbi, Ibraheem</au><au>Pen, Ally</au><au>Ruddy, Terrence D.</au><au>Chow, Benjamin J.W.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Assessment of left ventricular ejection fraction using low radiation dose computed tomography</atitle><jtitle>Journal of nuclear cardiology</jtitle><stitle>J. Nucl. Cardiol</stitle><addtitle>J Nucl Cardiol</addtitle><date>2016-06-01</date><risdate>2016</risdate><volume>23</volume><issue>3</issue><spage>414</spage><epage>421</epage><pages>414-421</pages><issn>1071-3581</issn><eissn>1532-6551</eissn><abstract>Cardiac CT is a non-invasive modality with the ability to estimate LVEF. However, given its limited temporal resolution and radiation, there has been initial resistance to use CT to measure LVEF. Developing an accurate, fast, low radiation dose protocol is desirable.
The objective of this study is to demonstrate that a ‘low radiation dose’ 64 slice cardiac computed tomography (CT) protocol is feasible and can accurately measure left ventricular ejection fraction (LVEF) while delivering a radiation dose lower than radionuclide angiography (RNA).
Patients undergoing RNA were prospectively screened and enrolled to undergo a ‘low-dose’ 64 slice CT LVEF protocol. LVEF measures, duration of each study and radiation dose between CT and RNA were compared.
A total of 77 patients (mean age = 61.8 ± 12.2 years and 58 men) were analyzed. The mean LVEF measured by CT and RNA were 41.9 ± 15.2% and 39.4 ± 13.9%, respectively, (P = 0.154) with a good correlation (r = 0.863). Bland-Altman plot revealed a good agreement between the CT and RNA LVEF (mean difference of −2.4). There was good agreement between CT LVEF and RNA for identifying patients with LVEF ≤30% (kappa = 0.693) and LVEF ≥50% (kappa = 0.749). The mean dose estimated effective dose for CT and RNA were 4.7 ± 1.6 and 9.5 ± 1.0 mSv, respectively. The mean CT LVEF imaging duration (4:32 ± 3:05 minutes) was significantly shorter than the RNA image acquisition time (9:05 ± 2:36 minutes; p < 0.001).
The results of our study suggest that low-dose CT LVEF protocol is feasible, accurate, and fast while delivering a lower radiation dose than traditional RNA.</abstract><cop>New York</cop><pub>Elsevier Inc</pub><pmid>26002814</pmid><doi>10.1007/s12350-015-0123-6</doi><tpages>8</tpages></addata></record> |
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| subjects | Cardiology Computed tomography ejection fraction Feasibility Studies Female Humans Imaging Male Medicine Medicine & Public Health Middle Aged Nuclear Medicine Original Article Radiation Dosage Radiation Protection - methods Radiographic Image Enhancement - methods Radiographic Image Interpretation, Computer-Assisted - methods Radiology radionuclide angiography Radionuclide Angiography - methods Reproducibility of Results Sensitivity and Specificity Stroke Volume Tomography, X-Ray Computed - methods Ventricular Dysfunction, Left - diagnostic imaging |
| title | Assessment of left ventricular ejection fraction using low radiation dose computed tomography |
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