Ligand independent aryl hydrocarbon receptor inhibits lung cancer cell invasion by degradation of Smad4
Highlights • Ligand-independent AhR showed tumor suppressor activity by inhibition of lung cancer cells invasion. • AhR affects the transforming growth factor-β signaling pathway by inducing Smad4 degradation by the proteasome and suppressing tumor metastasis via epithelial to mesenchymal transition...
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| Veröffentlicht in: | Cancer letters 2016-07, Vol.376 (2), p.211-217 |
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| container_title | Cancer letters |
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| creator | Lee, Chen-Chen Yang, Wen-Hao Li, Ching-Hao Cheng, Yu-Wen Tsai, Chi-Hao Kang, Jaw-Jou |
| description | Highlights • Ligand-independent AhR showed tumor suppressor activity by inhibition of lung cancer cells invasion. • AhR affects the transforming growth factor-β signaling pathway by inducing Smad4 degradation by the proteasome and suppressing tumor metastasis via epithelial to mesenchymal transition reduction in lung cancer cells. • AhR, Jab1, and Smad4 interacted and formed a complex that caused Smad4 ubiquitination. |
| doi_str_mv | 10.1016/j.canlet.2016.03.052 |
| format | Article |
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All rights reserved.</rights><rights>Copyright Elsevier Limited Jul 1, 2016</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c445t-b085501989996454bc1682e2024f49feb6a9ab8a46ca098a208a9234434b27b43</citedby><cites>FETCH-LOGICAL-c445t-b085501989996454bc1682e2024f49feb6a9ab8a46ca098a208a9234434b27b43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0304383516302130$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65534</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27060206$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lee, Chen-Chen</creatorcontrib><creatorcontrib>Yang, Wen-Hao</creatorcontrib><creatorcontrib>Li, Ching-Hao</creatorcontrib><creatorcontrib>Cheng, Yu-Wen</creatorcontrib><creatorcontrib>Tsai, Chi-Hao</creatorcontrib><creatorcontrib>Kang, Jaw-Jou</creatorcontrib><title>Ligand independent aryl hydrocarbon receptor inhibits lung cancer cell invasion by degradation of Smad4</title><title>Cancer letters</title><addtitle>Cancer Lett</addtitle><description>Highlights • Ligand-independent AhR showed tumor suppressor activity by inhibition of lung cancer cells invasion. • AhR affects the transforming growth factor-β signaling pathway by inducing Smad4 degradation by the proteasome and suppressing tumor metastasis via epithelial to mesenchymal transition reduction in lung cancer cells. • AhR, Jab1, and Smad4 interacted and formed a complex that caused Smad4 ubiquitination.</description><subject>Adenocarcinoma - genetics</subject><subject>Adenocarcinoma - metabolism</subject><subject>Adenocarcinoma - pathology</subject><subject>Adenocarcinoma of Lung</subject><subject>Aryl hydrocarbon receptor</subject><subject>Basic Helix-Loop-Helix Transcription Factors - genetics</subject><subject>Basic Helix-Loop-Helix Transcription Factors - metabolism</subject><subject>Carcinoma, Non-Small-Cell Lung - genetics</subject><subject>Carcinoma, Non-Small-Cell Lung - metabolism</subject><subject>Carcinoma, Non-Small-Cell Lung - pathology</subject><subject>Cell cycle</subject><subject>Cell growth</subject><subject>Cell Line, Tumor</subject><subject>Cell Movement</subject><subject>COP9 Signalosome Complex</subject><subject>Epithelial to mesenchymal transition</subject><subject>Epithelial-Mesenchymal Transition</subject><subject>Gene expression</subject><subject>Gene Expression Regulation, Neoplastic</subject><subject>Hematology, Oncology and Palliative Medicine</subject><subject>Humans</subject><subject>Inhibitor of Differentiation Protein 1 - metabolism</subject><subject>Intracellular Signaling Peptides and Proteins - metabolism</subject><subject>Jun-activation domain binding protein</subject><subject>Ligands</subject><subject>Lung cancer</subject><subject>Lung Neoplasms - genetics</subject><subject>Lung Neoplasms - metabolism</subject><subject>Lung Neoplasms - pathology</subject><subject>Metastasis</subject><subject>Neoplasm Invasiveness</subject><subject>Peptide Hydrolases - metabolism</subject><subject>Phenotype</subject><subject>Polycyclic aromatic hydrocarbons</subject><subject>Proteasome Endopeptidase Complex - metabolism</subject><subject>Protein expression</subject><subject>Proteins</subject><subject>Proteolysis</subject><subject>Receptors, Aryl Hydrocarbon - genetics</subject><subject>Receptors, Aryl Hydrocarbon - metabolism</subject><subject>RNA Interference</subject><subject>Rodents</subject><subject>Signal Transduction</subject><subject>Smad4</subject><subject>Smad4 Protein - metabolism</subject><subject>Snail Family Transcription Factors - metabolism</subject><subject>Studies</subject><subject>Transcription factors</subject><subject>Transfection</subject><subject>Transforming growth factor-β</subject><subject>Ubiquitination</subject><subject>Vimentin - metabolism</subject><issn>0304-3835</issn><issn>1872-7980</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkVtr3DAQhUVJabZp_0EJgjzbHV1sSy-BENILLPQh7bPQZbzRxmtvJW9g_31lNm0gL32RGObMHM43hHxiUDNg7edt7e044FzzUtUgamj4G7JiquNVpxWckRUIkJVQojkn73PeAkAju-YdOecdtMChXZHNOm7sGGgcA-6xPONMbToO9OEY0uRtctNIE3rcz1Mqqofo4pzpcBg3tPh7TNTjMJTOk82xaN2RBtwkG-y8lFNP73c2yA_kbW-HjB-f_wvy68vdz9tv1frH1--3N-vKS9nMlQPVNMC00lq3spHOs1Zx5MBlL3WPrrXaOmVl6y1oZTkoq7mQUkjHOyfFBbk67d2n6fcB82y20yGNxdKwTnVKMZBQVPKk8mnKOWFv9inuSm7DwCx0zdac6JqFrgFhCt0ydvm8_OB2GP4N_cVZBNcnAZaITxGTyT5ioRRiYTibMMX_Obxe4Ic4Rm-HRzxifsliMjdg7pcLLwdmrQDOBIg_eAGhRg</recordid><startdate>20160701</startdate><enddate>20160701</enddate><creator>Lee, Chen-Chen</creator><creator>Yang, Wen-Hao</creator><creator>Li, Ching-Hao</creator><creator>Cheng, Yu-Wen</creator><creator>Tsai, Chi-Hao</creator><creator>Kang, Jaw-Jou</creator><general>Elsevier Ireland Ltd</general><general>Elsevier Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TO</scope><scope>7U9</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope></search><sort><creationdate>20160701</creationdate><title>Ligand independent aryl hydrocarbon receptor inhibits lung cancer cell invasion by degradation of Smad4</title><author>Lee, Chen-Chen ; Yang, Wen-Hao ; Li, Ching-Hao ; Cheng, Yu-Wen ; Tsai, Chi-Hao ; Kang, Jaw-Jou</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c445t-b085501989996454bc1682e2024f49feb6a9ab8a46ca098a208a9234434b27b43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Adenocarcinoma - genetics</topic><topic>Adenocarcinoma - metabolism</topic><topic>Adenocarcinoma - pathology</topic><topic>Adenocarcinoma of Lung</topic><topic>Aryl hydrocarbon receptor</topic><topic>Basic Helix-Loop-Helix Transcription Factors - genetics</topic><topic>Basic Helix-Loop-Helix Transcription Factors - metabolism</topic><topic>Carcinoma, Non-Small-Cell Lung - genetics</topic><topic>Carcinoma, Non-Small-Cell Lung - metabolism</topic><topic>Carcinoma, Non-Small-Cell Lung - pathology</topic><topic>Cell cycle</topic><topic>Cell growth</topic><topic>Cell Line, Tumor</topic><topic>Cell Movement</topic><topic>COP9 Signalosome Complex</topic><topic>Epithelial to mesenchymal transition</topic><topic>Epithelial-Mesenchymal Transition</topic><topic>Gene expression</topic><topic>Gene Expression Regulation, Neoplastic</topic><topic>Hematology, Oncology and Palliative Medicine</topic><topic>Humans</topic><topic>Inhibitor of Differentiation Protein 1 - metabolism</topic><topic>Intracellular Signaling Peptides and Proteins - metabolism</topic><topic>Jun-activation domain binding protein</topic><topic>Ligands</topic><topic>Lung cancer</topic><topic>Lung Neoplasms - genetics</topic><topic>Lung Neoplasms - metabolism</topic><topic>Lung Neoplasms - pathology</topic><topic>Metastasis</topic><topic>Neoplasm Invasiveness</topic><topic>Peptide Hydrolases - metabolism</topic><topic>Phenotype</topic><topic>Polycyclic aromatic hydrocarbons</topic><topic>Proteasome Endopeptidase Complex - metabolism</topic><topic>Protein expression</topic><topic>Proteins</topic><topic>Proteolysis</topic><topic>Receptors, Aryl Hydrocarbon - genetics</topic><topic>Receptors, Aryl Hydrocarbon - metabolism</topic><topic>RNA Interference</topic><topic>Rodents</topic><topic>Signal Transduction</topic><topic>Smad4</topic><topic>Smad4 Protein - metabolism</topic><topic>Snail Family Transcription Factors - metabolism</topic><topic>Studies</topic><topic>Transcription factors</topic><topic>Transfection</topic><topic>Transforming growth factor-β</topic><topic>Ubiquitination</topic><topic>Vimentin - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lee, Chen-Chen</creatorcontrib><creatorcontrib>Yang, Wen-Hao</creatorcontrib><creatorcontrib>Li, Ching-Hao</creatorcontrib><creatorcontrib>Cheng, Yu-Wen</creatorcontrib><creatorcontrib>Tsai, Chi-Hao</creatorcontrib><creatorcontrib>Kang, Jaw-Jou</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><jtitle>Cancer letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lee, Chen-Chen</au><au>Yang, Wen-Hao</au><au>Li, Ching-Hao</au><au>Cheng, Yu-Wen</au><au>Tsai, Chi-Hao</au><au>Kang, Jaw-Jou</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Ligand independent aryl hydrocarbon receptor inhibits lung cancer cell invasion by degradation of Smad4</atitle><jtitle>Cancer letters</jtitle><addtitle>Cancer Lett</addtitle><date>2016-07-01</date><risdate>2016</risdate><volume>376</volume><issue>2</issue><spage>211</spage><epage>217</epage><pages>211-217</pages><issn>0304-3835</issn><eissn>1872-7980</eissn><abstract>Highlights • Ligand-independent AhR showed tumor suppressor activity by inhibition of lung cancer cells invasion. • AhR affects the transforming growth factor-β signaling pathway by inducing Smad4 degradation by the proteasome and suppressing tumor metastasis via epithelial to mesenchymal transition reduction in lung cancer cells. • AhR, Jab1, and Smad4 interacted and formed a complex that caused Smad4 ubiquitination.</abstract><cop>Ireland</cop><pub>Elsevier Ireland Ltd</pub><pmid>27060206</pmid><doi>10.1016/j.canlet.2016.03.052</doi><tpages>7</tpages></addata></record> |
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| issn | 0304-3835 1872-7980 |
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| subjects | Adenocarcinoma - genetics Adenocarcinoma - metabolism Adenocarcinoma - pathology Adenocarcinoma of Lung Aryl hydrocarbon receptor Basic Helix-Loop-Helix Transcription Factors - genetics Basic Helix-Loop-Helix Transcription Factors - metabolism Carcinoma, Non-Small-Cell Lung - genetics Carcinoma, Non-Small-Cell Lung - metabolism Carcinoma, Non-Small-Cell Lung - pathology Cell cycle Cell growth Cell Line, Tumor Cell Movement COP9 Signalosome Complex Epithelial to mesenchymal transition Epithelial-Mesenchymal Transition Gene expression Gene Expression Regulation, Neoplastic Hematology, Oncology and Palliative Medicine Humans Inhibitor of Differentiation Protein 1 - metabolism Intracellular Signaling Peptides and Proteins - metabolism Jun-activation domain binding protein Ligands Lung cancer Lung Neoplasms - genetics Lung Neoplasms - metabolism Lung Neoplasms - pathology Metastasis Neoplasm Invasiveness Peptide Hydrolases - metabolism Phenotype Polycyclic aromatic hydrocarbons Proteasome Endopeptidase Complex - metabolism Protein expression Proteins Proteolysis Receptors, Aryl Hydrocarbon - genetics Receptors, Aryl Hydrocarbon - metabolism RNA Interference Rodents Signal Transduction Smad4 Smad4 Protein - metabolism Snail Family Transcription Factors - metabolism Studies Transcription factors Transfection Transforming growth factor-β Ubiquitination Vimentin - metabolism |
| title | Ligand independent aryl hydrocarbon receptor inhibits lung cancer cell invasion by degradation of Smad4 |
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