Synthesis and study of the antifungal activity of new mono- and disubstituted derivatives of a genetically engineered polyene antibiotic 28,29-didehydronystatin A1 (S44HP)

Mono- and disubstituted novel derivatives of the heptaene nystatin analog 28,29-didehydronystatin A 1 (S44HP, 1 ) were obtained by chemical modification of the exocyclic C-16 carboxyl and/or an amino group of mycosamine moiety. The strategy of preparation of mono- and double-modified polyene macroli...

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