Development and use of a single-animal whole-body system for inhalation exposure
Inhalation exposure studies, in which test subjects are fully or partially immersed in an atmosphere containing a compound of interest, are usually carried out using one of two possible exposure systems: large whole-body chambers or systems that expose only the animal's nose or head. Whole-body...
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| Veröffentlicht in: | Lab animal 2008, Vol.37 (1), p.33-40 |
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| creator | Wong, B.A Ross, P.W James, R.A |
| description | Inhalation exposure studies, in which test subjects are fully or partially immersed in an atmosphere containing a compound of interest, are usually carried out using one of two possible exposure systems: large whole-body chambers or systems that expose only the animal's nose or head. Whole-body chambers may require large quantities of test compound, which can pose a problem if the chemical is expensive or available in limited quantities. Nose- or head-only systems can help conserve test compound but may cause stress or injury to animals. To address these concerns, the authors developed an exposure system consisting of small single-animal whole-body chambers. They exposed 80 mice and 80 rats to five test compounds at various concentrations. Though the system was labor-intensive for animal care technicians, it effectively exposed animals to precise chemical doses without causing adverse effects, using less test compound than would have been required in a conventional whole-body chamber. |
| doi_str_mv | 10.1038/laban0108-33 |
| format | Article |
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| subjects | Animal Models Animals Atmosphere Exposure Chambers Biomedical and Life Sciences Body Weight - drug effects Environmental impact analysis Equipment Design Female Hazardous substances Inhalation Exposure laboratory animals Life Sciences Male Methods Mice Mice, Inbred Strains Rats Rats as laboratory animals Rats, Inbred F344 resource Risk assessment Toxicity testing Toxicity Tests - instrumentation Toxicity Tests - methods Veterinary Medicine/Veterinary Science Xenobiotics - administration & dosage Xenobiotics - chemistry |
| title | Development and use of a single-animal whole-body system for inhalation exposure |
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