Perioperative Rosuvastatin in Cardiac Surgery
Patients undergoing cardiac surgery were randomly assigned to rosuvastatin or placebo. The groups did not differ significantly in the rate of postoperative atrial fibrillation or in the area under the troponin-release curve. Acute kidney injury was more common with rosuvastatin. Despite advances in...
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| Veröffentlicht in: | The New England journal of medicine 2016-05, Vol.374 (18), p.1744-1753 |
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| container_title | The New England journal of medicine |
| container_volume | 374 |
| creator | Zheng, Zhe Jayaram, Raja Jiang, Lixin Emberson, Jonathan Zhao, Yan Li, Qi Du, Juan Guarguagli, Silvia Hill, Michael Chen, Zhengming Collins, Rory Casadei, Barbara |
| description | Patients undergoing cardiac surgery were randomly assigned to rosuvastatin or placebo. The groups did not differ significantly in the rate of postoperative atrial fibrillation or in the area under the troponin-release curve. Acute kidney injury was more common with rosuvastatin.
Despite advances in surgical and perioperative care, postoperative complications after cardiac surgery remain frequent, leading to substantial increases in mortality, morbidity, and costs.
1
Inflammation and oxidative stress have been implicated in the pathogenesis of atrial fibrillation and other postoperative complications of cardiac surgery.
2
In particular, the incidence of postoperative atrial fibrillation coincides with the peak of the systemic inflammatory response after cardiac surgery,
2
is independently associated with atrial markers of oxidative stress,
3
,
4
and has been reported to be partially prevented by antiinflammatory drugs.
5
,
6
Statins have been shown to have rapid antiinflammatory and antioxidant effects
7
; for example, 3 . . . |
| doi_str_mv | 10.1056/NEJMoa1507750 |
| format | Article |
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Despite advances in surgical and perioperative care, postoperative complications after cardiac surgery remain frequent, leading to substantial increases in mortality, morbidity, and costs.
1
Inflammation and oxidative stress have been implicated in the pathogenesis of atrial fibrillation and other postoperative complications of cardiac surgery.
2
In particular, the incidence of postoperative atrial fibrillation coincides with the peak of the systemic inflammatory response after cardiac surgery,
2
is independently associated with atrial markers of oxidative stress,
3
,
4
and has been reported to be partially prevented by antiinflammatory drugs.
5
,
6
Statins have been shown to have rapid antiinflammatory and antioxidant effects
7
; for example, 3 . . .</description><identifier>ISSN: 0028-4793</identifier><identifier>EISSN: 1533-4406</identifier><identifier>DOI: 10.1056/NEJMoa1507750</identifier><identifier>PMID: 27144849</identifier><language>eng</language><publisher>United States: Massachusetts Medical Society</publisher><subject>Acute Kidney Injury - chemically induced ; Aged ; Atrial Fibrillation - prevention & control ; C-reactive protein ; C-Reactive Protein - analysis ; Calcium-binding protein ; Cardiac arrhythmia ; Cardiac Surgical Procedures ; Cholesterol ; Cholesterol, LDL - blood ; Clinical trials ; Drug therapy ; Elective Surgical Procedures ; Female ; Fibrillation ; Heart ; Heart attacks ; Heart surgery ; Humans ; Hydroxymethylglutaryl-CoA Reductase Inhibitors - adverse effects ; Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use ; Kidneys ; Male ; Middle Aged ; Morbidity ; Mortality ; Oxidative stress ; Perioperative Care ; Postoperative Complications - prevention & control ; Preventive medicine ; Renal function ; Rosuvastatin Calcium - adverse effects ; Rosuvastatin Calcium - therapeutic use ; Statins ; Troponin ; Troponin I ; Troponin I - blood ; Ventricle</subject><ispartof>The New England journal of medicine, 2016-05, Vol.374 (18), p.1744-1753</ispartof><rights>Copyright © 2016 Massachusetts Medical Society. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c390t-9183e88aee4c9786c95c810039b60b24c4fd5239ed4e51f32b4ada516da997723</citedby><cites>FETCH-LOGICAL-c390t-9183e88aee4c9786c95c810039b60b24c4fd5239ed4e51f32b4ada516da997723</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.nejm.org/doi/pdf/10.1056/NEJMoa1507750$$EPDF$$P50$$Gmms$$H</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/1787134984?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,780,784,2757,2758,26102,27923,27924,52381,54063,64384,64388,72240</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27144849$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zheng, Zhe</creatorcontrib><creatorcontrib>Jayaram, Raja</creatorcontrib><creatorcontrib>Jiang, Lixin</creatorcontrib><creatorcontrib>Emberson, Jonathan</creatorcontrib><creatorcontrib>Zhao, Yan</creatorcontrib><creatorcontrib>Li, Qi</creatorcontrib><creatorcontrib>Du, Juan</creatorcontrib><creatorcontrib>Guarguagli, Silvia</creatorcontrib><creatorcontrib>Hill, Michael</creatorcontrib><creatorcontrib>Chen, Zhengming</creatorcontrib><creatorcontrib>Collins, Rory</creatorcontrib><creatorcontrib>Casadei, Barbara</creatorcontrib><title>Perioperative Rosuvastatin in Cardiac Surgery</title><title>The New England journal of medicine</title><addtitle>N Engl J Med</addtitle><description>Patients undergoing cardiac surgery were randomly assigned to rosuvastatin or placebo. The groups did not differ significantly in the rate of postoperative atrial fibrillation or in the area under the troponin-release curve. Acute kidney injury was more common with rosuvastatin.
Despite advances in surgical and perioperative care, postoperative complications after cardiac surgery remain frequent, leading to substantial increases in mortality, morbidity, and costs.
1
Inflammation and oxidative stress have been implicated in the pathogenesis of atrial fibrillation and other postoperative complications of cardiac surgery.
2
In particular, the incidence of postoperative atrial fibrillation coincides with the peak of the systemic inflammatory response after cardiac surgery,
2
is independently associated with atrial markers of oxidative stress,
3
,
4
and has been reported to be partially prevented by antiinflammatory drugs.
5
,
6
Statins have been shown to have rapid antiinflammatory and antioxidant effects
7
; for example, 3 . . .</description><subject>Acute Kidney Injury - chemically induced</subject><subject>Aged</subject><subject>Atrial Fibrillation - prevention & control</subject><subject>C-reactive protein</subject><subject>C-Reactive Protein - analysis</subject><subject>Calcium-binding protein</subject><subject>Cardiac arrhythmia</subject><subject>Cardiac Surgical Procedures</subject><subject>Cholesterol</subject><subject>Cholesterol, LDL - blood</subject><subject>Clinical trials</subject><subject>Drug therapy</subject><subject>Elective Surgical Procedures</subject><subject>Female</subject><subject>Fibrillation</subject><subject>Heart</subject><subject>Heart attacks</subject><subject>Heart surgery</subject><subject>Humans</subject><subject>Hydroxymethylglutaryl-CoA Reductase Inhibitors - adverse effects</subject><subject>Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use</subject><subject>Kidneys</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Morbidity</subject><subject>Mortality</subject><subject>Oxidative stress</subject><subject>Perioperative Care</subject><subject>Postoperative Complications - prevention & control</subject><subject>Preventive medicine</subject><subject>Renal function</subject><subject>Rosuvastatin Calcium - adverse effects</subject><subject>Rosuvastatin Calcium - therapeutic use</subject><subject>Statins</subject><subject>Troponin</subject><subject>Troponin I</subject><subject>Troponin I - blood</subject><subject>Ventricle</subject><issn>0028-4793</issn><issn>1533-4406</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp1kE1LAzEQhoMotlaPXqUgHqPJZrJJjlLqF_UDP84hm52VLW63JruF_nsjrYIHh4HhhYd34CHkmLNzzmR-8TC9u28dl0wpyXbIkEshKADLd8mQsUxTUEYMyEGMc5aGg9kng0xxAA1mSOgThrpdYnBdvcLxcxv7lYtdSotx2okLZe38-KUP7xjWh2Svch8Rj7Z3RN6upq-TGzp7vL6dXM6oF4Z11HAtUGuHCN4onXsjveaMCVPkrMjAQ1XKTBgsASWvRFaAK53keemMUSoTI3K66V2G9rPH2Nl524dFemm50ooLMBoSRTeUD22MASu7DHXjwtpyZr_l2D9yEn-ybe2LBstf-sdGAs42QNNEu8B580_RFyhFaSs</recordid><startdate>20160505</startdate><enddate>20160505</enddate><creator>Zheng, Zhe</creator><creator>Jayaram, Raja</creator><creator>Jiang, Lixin</creator><creator>Emberson, Jonathan</creator><creator>Zhao, Yan</creator><creator>Li, Qi</creator><creator>Du, Juan</creator><creator>Guarguagli, Silvia</creator><creator>Hill, Michael</creator><creator>Chen, Zhengming</creator><creator>Collins, Rory</creator><creator>Casadei, Barbara</creator><general>Massachusetts Medical Society</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>0TZ</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BEC</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K0Y</scope><scope>LK8</scope><scope>M0R</scope><scope>M0T</scope><scope>M1P</scope><scope>M2M</scope><scope>M2O</scope><scope>M2P</scope><scope>M7P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope></search><sort><creationdate>20160505</creationdate><title>Perioperative Rosuvastatin in Cardiac Surgery</title><author>Zheng, Zhe ; Jayaram, Raja ; Jiang, Lixin ; Emberson, Jonathan ; Zhao, Yan ; Li, Qi ; Du, Juan ; Guarguagli, Silvia ; Hill, Michael ; Chen, Zhengming ; Collins, Rory ; Casadei, Barbara</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c390t-9183e88aee4c9786c95c810039b60b24c4fd5239ed4e51f32b4ada516da997723</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Acute Kidney Injury - chemically induced</topic><topic>Aged</topic><topic>Atrial Fibrillation - prevention & control</topic><topic>C-reactive protein</topic><topic>C-Reactive Protein - analysis</topic><topic>Calcium-binding protein</topic><topic>Cardiac arrhythmia</topic><topic>Cardiac Surgical Procedures</topic><topic>Cholesterol</topic><topic>Cholesterol, LDL - blood</topic><topic>Clinical trials</topic><topic>Drug therapy</topic><topic>Elective Surgical Procedures</topic><topic>Female</topic><topic>Fibrillation</topic><topic>Heart</topic><topic>Heart attacks</topic><topic>Heart surgery</topic><topic>Humans</topic><topic>Hydroxymethylglutaryl-CoA Reductase Inhibitors - adverse effects</topic><topic>Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use</topic><topic>Kidneys</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Morbidity</topic><topic>Mortality</topic><topic>Oxidative stress</topic><topic>Perioperative Care</topic><topic>Postoperative Complications - prevention & control</topic><topic>Preventive medicine</topic><topic>Renal function</topic><topic>Rosuvastatin Calcium - adverse effects</topic><topic>Rosuvastatin Calcium - therapeutic use</topic><topic>Statins</topic><topic>Troponin</topic><topic>Troponin I</topic><topic>Troponin I - blood</topic><topic>Ventricle</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zheng, Zhe</creatorcontrib><creatorcontrib>Jayaram, Raja</creatorcontrib><creatorcontrib>Jiang, Lixin</creatorcontrib><creatorcontrib>Emberson, Jonathan</creatorcontrib><creatorcontrib>Zhao, Yan</creatorcontrib><creatorcontrib>Li, Qi</creatorcontrib><creatorcontrib>Du, Juan</creatorcontrib><creatorcontrib>Guarguagli, Silvia</creatorcontrib><creatorcontrib>Hill, Michael</creatorcontrib><creatorcontrib>Chen, Zhengming</creatorcontrib><creatorcontrib>Collins, Rory</creatorcontrib><creatorcontrib>Casadei, Barbara</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Pharma and Biotech Premium PRO</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>eLibrary</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>SciTech Premium Collection</collection><collection>New England Journal of Medicine</collection><collection>ProQuest Biological Science Collection</collection><collection>Consumer Health Database</collection><collection>Healthcare Administration Database</collection><collection>Medical Database</collection><collection>Psychology Database</collection><collection>Research Library</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><jtitle>The New England journal of medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zheng, Zhe</au><au>Jayaram, Raja</au><au>Jiang, Lixin</au><au>Emberson, Jonathan</au><au>Zhao, Yan</au><au>Li, Qi</au><au>Du, Juan</au><au>Guarguagli, Silvia</au><au>Hill, Michael</au><au>Chen, Zhengming</au><au>Collins, Rory</au><au>Casadei, Barbara</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Perioperative Rosuvastatin in Cardiac Surgery</atitle><jtitle>The New England journal of medicine</jtitle><addtitle>N Engl J Med</addtitle><date>2016-05-05</date><risdate>2016</risdate><volume>374</volume><issue>18</issue><spage>1744</spage><epage>1753</epage><pages>1744-1753</pages><issn>0028-4793</issn><eissn>1533-4406</eissn><abstract>Patients undergoing cardiac surgery were randomly assigned to rosuvastatin or placebo. The groups did not differ significantly in the rate of postoperative atrial fibrillation or in the area under the troponin-release curve. Acute kidney injury was more common with rosuvastatin.
Despite advances in surgical and perioperative care, postoperative complications after cardiac surgery remain frequent, leading to substantial increases in mortality, morbidity, and costs.
1
Inflammation and oxidative stress have been implicated in the pathogenesis of atrial fibrillation and other postoperative complications of cardiac surgery.
2
In particular, the incidence of postoperative atrial fibrillation coincides with the peak of the systemic inflammatory response after cardiac surgery,
2
is independently associated with atrial markers of oxidative stress,
3
,
4
and has been reported to be partially prevented by antiinflammatory drugs.
5
,
6
Statins have been shown to have rapid antiinflammatory and antioxidant effects
7
; for example, 3 . . .</abstract><cop>United States</cop><pub>Massachusetts Medical Society</pub><pmid>27144849</pmid><doi>10.1056/NEJMoa1507750</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0028-4793 |
| ispartof | The New England journal of medicine, 2016-05, Vol.374 (18), p.1744-1753 |
| issn | 0028-4793 1533-4406 |
| language | eng |
| recordid | cdi_proquest_journals_1787134984 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; ProQuest Central UK/Ireland; New England Journal of Medicine |
| subjects | Acute Kidney Injury - chemically induced Aged Atrial Fibrillation - prevention & control C-reactive protein C-Reactive Protein - analysis Calcium-binding protein Cardiac arrhythmia Cardiac Surgical Procedures Cholesterol Cholesterol, LDL - blood Clinical trials Drug therapy Elective Surgical Procedures Female Fibrillation Heart Heart attacks Heart surgery Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors - adverse effects Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use Kidneys Male Middle Aged Morbidity Mortality Oxidative stress Perioperative Care Postoperative Complications - prevention & control Preventive medicine Renal function Rosuvastatin Calcium - adverse effects Rosuvastatin Calcium - therapeutic use Statins Troponin Troponin I Troponin I - blood Ventricle |
| title | Perioperative Rosuvastatin in Cardiac Surgery |
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