Fractalkine (CX3CL1)
BackgroundElevated serum and synovial fluid (SF) fractalkine (CX3CL1) levels have been detected in patients with knee osteoarthritis (OA). The current study was carried out to investigate the association between serum and SF fractalkine levels with symptomatic severity in patients with knee OA.Metho...
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| Veröffentlicht in: | Journal of investigative medicine 2015-04, Vol.63 (4), p.626 |
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| container_title | Journal of investigative medicine |
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| creator | Huo, Li Wei Ye, Yong Liang Wang, Guang Wei Ye, Yong Guang |
| description | BackgroundElevated serum and synovial fluid (SF) fractalkine (CX3CL1) levels have been detected in patients with knee osteoarthritis (OA). The current study was carried out to investigate the association between serum and SF fractalkine levels with symptomatic severity in patients with knee OA.MethodOne hundred ninety-three patients with OA and 182 healthy controls were enrolled in this study. The symptomatic severity was assessed by the Western Ontario McMaster University Osteoarthritis scores.ResultsFractalkine levels in SF and serum were both positively associated with self-reported greater pain and physical disability.ConclusionsFractalkine in SF and serum may serve as a biomarker for reflecting symptomatic severity. Therapeutic interventions that target fractalkine signaling pathways to delay OA-related symptoms deserve further study. |
| doi_str_mv | 10.1097/JIM.0000000000000158 |
| format | Article |
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The current study was carried out to investigate the association between serum and SF fractalkine levels with symptomatic severity in patients with knee OA.MethodOne hundred ninety-three patients with OA and 182 healthy controls were enrolled in this study. The symptomatic severity was assessed by the Western Ontario McMaster University Osteoarthritis scores.ResultsFractalkine levels in SF and serum were both positively associated with self-reported greater pain and physical disability.ConclusionsFractalkine in SF and serum may serve as a biomarker for reflecting symptomatic severity. Therapeutic interventions that target fractalkine signaling pathways to delay OA-related symptoms deserve further study.</description><identifier>ISSN: 1081-5589</identifier><identifier>EISSN: 1708-8267</identifier><identifier>DOI: 10.1097/JIM.0000000000000158</identifier><identifier>PMID: 25692263</identifier><language>eng</language><publisher>London: Sage Publications Ltd</publisher><ispartof>Journal of investigative medicine, 2015-04, Vol.63 (4), p.626</ispartof><rights>2015 American Federation for Medical Research, Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions</rights><rights>Copyright: 2015 (c) 2015 American Federation for Medical Research, Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids></links><search><creatorcontrib>Huo, Li Wei</creatorcontrib><creatorcontrib>Ye, Yong Liang</creatorcontrib><creatorcontrib>Wang, Guang Wei</creatorcontrib><creatorcontrib>Ye, Yong Guang</creatorcontrib><title>Fractalkine (CX3CL1)</title><title>Journal of investigative medicine</title><description>BackgroundElevated serum and synovial fluid (SF) fractalkine (CX3CL1) levels have been detected in patients with knee osteoarthritis (OA). The current study was carried out to investigate the association between serum and SF fractalkine levels with symptomatic severity in patients with knee OA.MethodOne hundred ninety-three patients with OA and 182 healthy controls were enrolled in this study. The symptomatic severity was assessed by the Western Ontario McMaster University Osteoarthritis scores.ResultsFractalkine levels in SF and serum were both positively associated with self-reported greater pain and physical disability.ConclusionsFractalkine in SF and serum may serve as a biomarker for reflecting symptomatic severity. 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The current study was carried out to investigate the association between serum and SF fractalkine levels with symptomatic severity in patients with knee OA.MethodOne hundred ninety-three patients with OA and 182 healthy controls were enrolled in this study. The symptomatic severity was assessed by the Western Ontario McMaster University Osteoarthritis scores.ResultsFractalkine levels in SF and serum were both positively associated with self-reported greater pain and physical disability.ConclusionsFractalkine in SF and serum may serve as a biomarker for reflecting symptomatic severity. Therapeutic interventions that target fractalkine signaling pathways to delay OA-related symptoms deserve further study.</abstract><cop>London</cop><pub>Sage Publications Ltd</pub><pmid>25692263</pmid><doi>10.1097/JIM.0000000000000158</doi></addata></record> |
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| title | Fractalkine (CX3CL1) |
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