FoxO3a is activated and executes neuron death via Bim in response to [beta]-amyloid

The molecules that mediate death of selective neurons in Alzheimer's disease (AD) are mostly unknown. The Forkhead transcription factor FoxO3a has emerged as an important mediator of cell fate including apoptosis. When phosphorylated by Akt, it is localized in the cytosol as an inactive complex...

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Veröffentlicht in:	Cell death & disease 2013-05, Vol.4, p.e625
Hauptverfasser:	Sanphui, P, Biswas, S C
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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