A case of cardiogenic shock caused by capecitabine treatment
Several chemotherapeutic agents, including newer drugs, can have toxic cardiac effects. In this month's Case Study, To and colleagues present their patient who had capecitabine-induced cardiogenic shock. They examine the best course of action for this serious complication of chemotherapy. Backg...
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| Veröffentlicht in: | Nature clinical practice cardiovascular medicine 2008-11, Vol.5 (11), p.725-729 |
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| creator | To, Andrew CY Looi, Khang Li Damianovich, Dragan Taylor, Graeme B Sidebotham, David White, Harvey D |
| description | Several chemotherapeutic agents, including newer drugs, can have toxic cardiac effects. In this month's Case Study, To and colleagues present their patient who had capecitabine-induced cardiogenic shock. They examine the best course of action for this serious complication of chemotherapy.
Background
A 52-year-old woman underwent successful resection of stage IIB primary mucinous adenocarcinoma of the appendix and was started on capecitabine chemotherapy. Five days into the first course, after initially experiencing diarrhea, nausea, vomiting and a transient episode of retrosternal chest pain radiating to the left scapula, she presented to the emergency department with cardiogenic shock.
Investigations
Electrocardiography, transthoracic echocardiography, laboratory investigation of cardiac biomarkers, coronary angiography and endomyocardial biopsy.
Diagnosis
Capecitabine-induced cardiogenic shock.
Management
Supportive treatment with dopamine, milrinone, norepinephrine (noradrenaline) and levosimendan. |
| doi_str_mv | 10.1038/ncpcardio1352 |
| format | Article |
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Background
A 52-year-old woman underwent successful resection of stage IIB primary mucinous adenocarcinoma of the appendix and was started on capecitabine chemotherapy. Five days into the first course, after initially experiencing diarrhea, nausea, vomiting and a transient episode of retrosternal chest pain radiating to the left scapula, she presented to the emergency department with cardiogenic shock.
Investigations
Electrocardiography, transthoracic echocardiography, laboratory investigation of cardiac biomarkers, coronary angiography and endomyocardial biopsy.
Diagnosis
Capecitabine-induced cardiogenic shock.
Management
Supportive treatment with dopamine, milrinone, norepinephrine (noradrenaline) and levosimendan.</description><identifier>ISSN: 1743-4297</identifier><identifier>ISSN: 1759-5002</identifier><identifier>EISSN: 1743-4300</identifier><identifier>EISSN: 1759-5010</identifier><identifier>DOI: 10.1038/ncpcardio1352</identifier><identifier>PMID: 18813211</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>Adenocarcinoma, Mucinous - drug therapy ; Adenocarcinoma, Mucinous - surgery ; Antimetabolites, Antineoplastic - adverse effects ; Appendiceal Neoplasms - drug therapy ; Appendiceal Neoplasms - surgery ; Biomarkers - blood ; Biopsy ; Capecitabine ; Cardiac Imaging ; Cardiac Surgery ; Cardiogenic shock ; Cardiology ; Cardiotonic Agents - therapeutic use ; Care and treatment ; Case studies ; case-study ; Chemotherapy, Adjuvant ; Complications and side effects ; Coronary Angiography ; Deoxycytidine - adverse effects ; Deoxycytidine - analogs & derivatives ; Diagnosis ; Echocardiography ; Electrocardiography ; Female ; Fluorouracil - adverse effects ; Fluorouracil - analogs & derivatives ; Humans ; Medicine ; Medicine & Public Health ; Middle Aged ; Patient outcomes ; Risk factors ; Shock, Cardiogenic - chemically induced ; Shock, Cardiogenic - drug therapy ; Shock, Cardiogenic - pathology ; Treatment Outcome</subject><ispartof>Nature clinical practice cardiovascular medicine, 2008-11, Vol.5 (11), p.725-729</ispartof><rights>Springer Nature Limited 2008</rights><rights>COPYRIGHT 2008 Nature Publishing Group</rights><rights>Copyright Nature Publishing Group Nov 2008</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c453t-e57d966407324b18f22891fb147af8cf160e1d01d40710a786066b96f94fb8ec3</citedby><cites>FETCH-LOGICAL-c453t-e57d966407324b18f22891fb147af8cf160e1d01d40710a786066b96f94fb8ec3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,2725,27923,27924</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18813211$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>To, Andrew CY</creatorcontrib><creatorcontrib>Looi, Khang Li</creatorcontrib><creatorcontrib>Damianovich, Dragan</creatorcontrib><creatorcontrib>Taylor, Graeme B</creatorcontrib><creatorcontrib>Sidebotham, David</creatorcontrib><creatorcontrib>White, Harvey D</creatorcontrib><title>A case of cardiogenic shock caused by capecitabine treatment</title><title>Nature clinical practice cardiovascular medicine</title><addtitle>Nat Rev Cardiol</addtitle><addtitle>Nat Clin Pract Cardiovasc Med</addtitle><description>Several chemotherapeutic agents, including newer drugs, can have toxic cardiac effects. In this month's Case Study, To and colleagues present their patient who had capecitabine-induced cardiogenic shock. They examine the best course of action for this serious complication of chemotherapy.
Background
A 52-year-old woman underwent successful resection of stage IIB primary mucinous adenocarcinoma of the appendix and was started on capecitabine chemotherapy. Five days into the first course, after initially experiencing diarrhea, nausea, vomiting and a transient episode of retrosternal chest pain radiating to the left scapula, she presented to the emergency department with cardiogenic shock.
Investigations
Electrocardiography, transthoracic echocardiography, laboratory investigation of cardiac biomarkers, coronary angiography and endomyocardial biopsy.
Diagnosis
Capecitabine-induced cardiogenic shock.
Management
Supportive treatment with dopamine, milrinone, norepinephrine (noradrenaline) and levosimendan.</description><subject>Adenocarcinoma, Mucinous - drug therapy</subject><subject>Adenocarcinoma, Mucinous - surgery</subject><subject>Antimetabolites, Antineoplastic - adverse effects</subject><subject>Appendiceal Neoplasms - drug therapy</subject><subject>Appendiceal Neoplasms - surgery</subject><subject>Biomarkers - blood</subject><subject>Biopsy</subject><subject>Capecitabine</subject><subject>Cardiac Imaging</subject><subject>Cardiac Surgery</subject><subject>Cardiogenic shock</subject><subject>Cardiology</subject><subject>Cardiotonic Agents - therapeutic use</subject><subject>Care and treatment</subject><subject>Case studies</subject><subject>case-study</subject><subject>Chemotherapy, Adjuvant</subject><subject>Complications and side effects</subject><subject>Coronary Angiography</subject><subject>Deoxycytidine - adverse effects</subject><subject>Deoxycytidine - analogs & derivatives</subject><subject>Diagnosis</subject><subject>Echocardiography</subject><subject>Electrocardiography</subject><subject>Female</subject><subject>Fluorouracil - adverse effects</subject><subject>Fluorouracil - analogs & derivatives</subject><subject>Humans</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Patient outcomes</subject><subject>Risk factors</subject><subject>Shock, Cardiogenic - chemically induced</subject><subject>Shock, Cardiogenic - drug therapy</subject><subject>Shock, Cardiogenic - pathology</subject><subject>Treatment Outcome</subject><issn>1743-4297</issn><issn>1759-5002</issn><issn>1743-4300</issn><issn>1759-5010</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp1kU1PwzAMhiMEYjA4ckWVOHfETdukEpdp4kuaxAXOVZo6I2NNR9Ie9u_JtMKYBMohlvP4td-YkCugE6BM3Fq1VtLVpgWWJUfkDHjK4pRRevwdJwUfkXPvl5Qyzpk4JSMQAlgCcEbuppGSHqNWRzuZBVqjIv_eqo-Q6T3WUbUJ0RqV6WRlLEadQ9k1aLsLcqLlyuPlcI_J28P96-wpnr88Ps-m81ilGetizHhd5HlKOUvSCoROElGAriDlUgulIacINYU6EEAlFznN86rIdZHqSqBiY3Kz01279rNH35XLtnc2tCyBizTLRSayPbWQKyyN1W3npGqMV-UUiuCdJcWWmvxBhVNjY1RrUZuQPyiIdwXKtd471OXamUa6TQm03K6gPFhB4K-HYfuqwXpPD3--n8CHJ7tA98vNP4qDMSu73uGP4iH1BUkPnOI</recordid><startdate>20081101</startdate><enddate>20081101</enddate><creator>To, Andrew CY</creator><creator>Looi, Khang Li</creator><creator>Damianovich, Dragan</creator><creator>Taylor, Graeme B</creator><creator>Sidebotham, David</creator><creator>White, Harvey D</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope></search><sort><creationdate>20081101</creationdate><title>A case of cardiogenic shock caused by capecitabine treatment</title><author>To, Andrew CY ; Looi, Khang Li ; Damianovich, Dragan ; Taylor, Graeme B ; Sidebotham, David ; White, Harvey D</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c453t-e57d966407324b18f22891fb147af8cf160e1d01d40710a786066b96f94fb8ec3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Adenocarcinoma, Mucinous - drug therapy</topic><topic>Adenocarcinoma, Mucinous - surgery</topic><topic>Antimetabolites, Antineoplastic - adverse effects</topic><topic>Appendiceal Neoplasms - drug therapy</topic><topic>Appendiceal Neoplasms - surgery</topic><topic>Biomarkers - blood</topic><topic>Biopsy</topic><topic>Capecitabine</topic><topic>Cardiac Imaging</topic><topic>Cardiac Surgery</topic><topic>Cardiogenic shock</topic><topic>Cardiology</topic><topic>Cardiotonic Agents - therapeutic use</topic><topic>Care and treatment</topic><topic>Case studies</topic><topic>case-study</topic><topic>Chemotherapy, Adjuvant</topic><topic>Complications and side effects</topic><topic>Coronary Angiography</topic><topic>Deoxycytidine - adverse effects</topic><topic>Deoxycytidine - analogs & derivatives</topic><topic>Diagnosis</topic><topic>Echocardiography</topic><topic>Electrocardiography</topic><topic>Female</topic><topic>Fluorouracil - adverse effects</topic><topic>Fluorouracil - analogs & derivatives</topic><topic>Humans</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Patient outcomes</topic><topic>Risk factors</topic><topic>Shock, Cardiogenic - chemically induced</topic><topic>Shock, Cardiogenic - drug therapy</topic><topic>Shock, Cardiogenic - pathology</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>To, Andrew CY</creatorcontrib><creatorcontrib>Looi, Khang Li</creatorcontrib><creatorcontrib>Damianovich, Dragan</creatorcontrib><creatorcontrib>Taylor, Graeme B</creatorcontrib><creatorcontrib>Sidebotham, David</creatorcontrib><creatorcontrib>White, Harvey D</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><jtitle>Nature clinical practice cardiovascular medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>To, Andrew CY</au><au>Looi, Khang Li</au><au>Damianovich, Dragan</au><au>Taylor, Graeme B</au><au>Sidebotham, David</au><au>White, Harvey D</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A case of cardiogenic shock caused by capecitabine treatment</atitle><jtitle>Nature clinical practice cardiovascular medicine</jtitle><stitle>Nat Rev Cardiol</stitle><addtitle>Nat Clin Pract Cardiovasc Med</addtitle><date>2008-11-01</date><risdate>2008</risdate><volume>5</volume><issue>11</issue><spage>725</spage><epage>729</epage><pages>725-729</pages><issn>1743-4297</issn><issn>1759-5002</issn><eissn>1743-4300</eissn><eissn>1759-5010</eissn><abstract>Several chemotherapeutic agents, including newer drugs, can have toxic cardiac effects. In this month's Case Study, To and colleagues present their patient who had capecitabine-induced cardiogenic shock. They examine the best course of action for this serious complication of chemotherapy.
Background
A 52-year-old woman underwent successful resection of stage IIB primary mucinous adenocarcinoma of the appendix and was started on capecitabine chemotherapy. Five days into the first course, after initially experiencing diarrhea, nausea, vomiting and a transient episode of retrosternal chest pain radiating to the left scapula, she presented to the emergency department with cardiogenic shock.
Investigations
Electrocardiography, transthoracic echocardiography, laboratory investigation of cardiac biomarkers, coronary angiography and endomyocardial biopsy.
Diagnosis
Capecitabine-induced cardiogenic shock.
Management
Supportive treatment with dopamine, milrinone, norepinephrine (noradrenaline) and levosimendan.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>18813211</pmid><doi>10.1038/ncpcardio1352</doi><tpages>5</tpages></addata></record> |
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| subjects | Adenocarcinoma, Mucinous - drug therapy Adenocarcinoma, Mucinous - surgery Antimetabolites, Antineoplastic - adverse effects Appendiceal Neoplasms - drug therapy Appendiceal Neoplasms - surgery Biomarkers - blood Biopsy Capecitabine Cardiac Imaging Cardiac Surgery Cardiogenic shock Cardiology Cardiotonic Agents - therapeutic use Care and treatment Case studies case-study Chemotherapy, Adjuvant Complications and side effects Coronary Angiography Deoxycytidine - adverse effects Deoxycytidine - analogs & derivatives Diagnosis Echocardiography Electrocardiography Female Fluorouracil - adverse effects Fluorouracil - analogs & derivatives Humans Medicine Medicine & Public Health Middle Aged Patient outcomes Risk factors Shock, Cardiogenic - chemically induced Shock, Cardiogenic - drug therapy Shock, Cardiogenic - pathology Treatment Outcome |
| title | A case of cardiogenic shock caused by capecitabine treatment |
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