Biocatalytic Approach for the Total Synthesis of (-)-Malyngolide and Its C(5)-Epimer

Biocatalytic Approach for the Total Synthesis of (-)-Malyngolide and Its C(5)-Epimer

An enzymatic approach has been successfully utilized in the total synthesis of (–)‐malyngolide and its C(5)‐epimer. The required configuration was established by an enzymatic kinetic resolution and Sharpless asymmetric dihydroxylation.

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Bibliographische Detailangaben
Veröffentlicht in:Helvetica chimica acta 2016-04, Vol.99 (4), p.267-272
Hauptverfasser: Srivastava, Nikhil, Subba Reddy, Basi V.
Format: Artikel
Sprache:eng
Schlagworte:
Antibiotic activity
Asymmetric dihydroxylation
Enzymatic resolution
Malyngolide
δ-Lactone
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Beschreibung
Zusammenfassung:An enzymatic approach has been successfully utilized in the total synthesis of (–)‐malyngolide and its C(5)‐epimer. The required configuration was established by an enzymatic kinetic resolution and Sharpless asymmetric dihydroxylation.
ISSN:0018-019X
1522-2675
DOI:10.1002/hlca.201500237