Aspirin-triggered resolvin D1 reduces mucosal inflammation and promotes resolution in a murine model of acute lung injury

Acute lung injury (ALI) is a severe illness with excess mortality and no specific therapy. Protective actions were recently uncovered for docosahexaenoic acid-derived mediators, including D-series resolvins. Here, we used a murine self-limited model of hydrochloric acid-induced ALI to determine the...

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Veröffentlicht in:	Mucosal immunology 2013-03, Vol.6 (2), p.256-266
Hauptverfasser:	Eickmeier, O, Seki, H, Haworth, O, Hilberath, J N, Gao, F, Uddin, M, Croze, R H, Carlo, T, Pfeffer, M A, Levy, B D
Format:	Artikel
Sprache:	eng
Schlagworte:	631/250/347 631/250/516/1909 692/699/1785 Acute Lung Injury - metabolism Acute Lung Injury - pathology Adaptor Proteins, Signal Transducing - metabolism Airway Resistance Allergology Animals Anti-Inflammatory Agents, Non-Steroidal - administration & dosage Anti-Inflammatory Agents, Non-Steroidal - pharmacology Antibodies Aspirin - administration & dosage Aspirin - pharmacology Biomedical and Life Sciences Biomedicine Blood Platelets - metabolism Blood-Air Barrier - physiopathology Disease Models, Animal Docosahexaenoic Acids - biosynthesis Docosahexaenoic Acids - metabolism Epinephrine - metabolism Gastroenterology Immunology Inflammation - immunology Inflammation - metabolism Inflammation Mediators - metabolism Leukocytes - immunology Macrophages, Alveolar - metabolism Male Mice Neutrophils - immunology Pulmonary Edema - immunology Pulmonary Edema - metabolism Pulmonary Edema - pathology Receptors, Formyl Peptide - metabolism Respiratory Mucosa - metabolism Respiratory Mucosa - pathology Transcription Factor RelA - metabolism
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