P219 Ten year mortality in a primary care COPD cohort: multidimensional index BOD more discriminant than GOLD staging
Of potential prognostic variables for COPD to use in a multidimensional staging tool, BMI, severity of airflow obstruction (FEV1% predicted) and the MRC Dyspnoea Score (BOD) have been shown to be useful for a more complete assessment of the impact of the disease.1 In 1999–2002 we identified 431 pati...
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| Veröffentlicht in: | Thorax 2011-12, Vol.66 (Suppl 4), p.A157-A157 |
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| description | Of potential prognostic variables for COPD to use in a multidimensional staging tool, BMI, severity of airflow obstruction (FEV1% predicted) and the MRC Dyspnoea Score (BOD) have been shown to be useful for a more complete assessment of the impact of the disease.1 In 1999–2002 we identified 431 patients (208 women) with COPD in primary care surgeries and recorded their BOD scores (maximum 7). For men and women (mean±SD): age was 66±10 and 64±10; pack/years 34±19 and 34±18; BMI 27±5 and 25±6; FEV1% predicted 55±15 and 57±16; and MRC Dyspnoea Score 2.6±1.0 and 2.6±1.0; with BOD scores 1.9±1.5 and 2.0±1.6 respectively. The low mean BOD scores indicate the mainly moderate severity for this primary care cohort (only one subject had an MRC score of 5). Because of the similarities in these variables for men and women further analysis is of the whole cohort. Mortality was assessed in October 2010 and a Kaplan–Meier analysis for those with BOD scores 0 and 1 shows 80% and 75% probability of survival, whereas for a BOD score of >4 the 10-year survival was 4)BSEWald (df=1)p ValueExp (B) (95% CI)BOD quartiles0.6270.12624.889 |
| doi_str_mv | 10.1136/thoraxjnl-2011-201054c.219 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_journals_1781812870</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>4027102661</sourcerecordid><originalsourceid>FETCH-LOGICAL-b2729-617e5216c76281161d77d95df20897d9233b817747d00196227836b7a3df09813</originalsourceid><addsrcrecordid>eNqVkM9OAyEQh4nRxPrnHYieVxnoAutNW60m1XqoPXghdJcqdZdVoLG9efFFfRJp2nj3Mszh-80MH0InQM4AGD-Pr63Xy7mrM0oA1oXk3fKMQrGDOtDlMmO04LuoQ0iXZJwJvo8OQpgTQiSA6KDPx8T-fH2PjcMroz1uWh91beMKW4c1fve20X6FS-0N7o0e-7hs0854gZtFHW1lG-OCbZ2uE1-ZJb4a9dczDK5sKFPYOu0ijq_a4cFo2Mch6hfrXo7Q3kzXwRxv30P0dHM97t1mw9Hgrnc5zKZU0CLjIExOgZeC03Qwh0qIqsirGSWySB1lbCpBiK6oCIGCUyok41OhWTUjhQR2iE43c999-7EwIap5u_Dp3KBASJBApSCJuthQpW9D8Gamtv9WQNRatPoTrdai1Va0SvJSONuEbYhm-ZfU_k1xwUSuHiY9NRnATUHYs7pPfL7hp838P3t-ASCfk2o</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1781812870</pqid></control><display><type>article</type><title>P219 Ten year mortality in a primary care COPD cohort: multidimensional index BOD more discriminant than GOLD staging</title><source>BMJ Journals - NESLi2</source><source>Alma/SFX Local Collection</source><creator>Keaney, N P ; Ansari, K ; Munby, J ; Price, M ; Kay, A ; Taylor, I K</creator><creatorcontrib>Keaney, N P ; Ansari, K ; Munby, J ; Price, M ; Kay, A ; Taylor, I K</creatorcontrib><description>Of potential prognostic variables for COPD to use in a multidimensional staging tool, BMI, severity of airflow obstruction (FEV1% predicted) and the MRC Dyspnoea Score (BOD) have been shown to be useful for a more complete assessment of the impact of the disease.1 In 1999–2002 we identified 431 patients (208 women) with COPD in primary care surgeries and recorded their BOD scores (maximum 7). For men and women (mean±SD): age was 66±10 and 64±10; pack/years 34±19 and 34±18; BMI 27±5 and 25±6; FEV1% predicted 55±15 and 57±16; and MRC Dyspnoea Score 2.6±1.0 and 2.6±1.0; with BOD scores 1.9±1.5 and 2.0±1.6 respectively. The low mean BOD scores indicate the mainly moderate severity for this primary care cohort (only one subject had an MRC score of 5). Because of the similarities in these variables for men and women further analysis is of the whole cohort. Mortality was assessed in October 2010 and a Kaplan–Meier analysis for those with BOD scores 0 and 1 shows 80% and 75% probability of survival, whereas for a BOD score of >4 the 10-year survival was <20%. By way of contrast GOLD stages 1 and 2 had a 75% and 60% survival with Stage 4 showing a 60% survival. The Cox regression model (Abstract P219 table 1) demonstrated that BOD was a better predictor of survival than age and that smoking history was a significant covariate. Ten year survival was <10% when smoking history (with age and co-morbidity score) was added to a BOD score of >4 in a Kaplan–Meier plot.Abstract P219 Table 1Cox regression model with covariates influencing COPD mortality. (BOD quartiles: 0, 1, 2–4 and >4)BSEWald (df=1)p ValueExp (B) (95% CI)BOD quartiles0.6270.12624.889<0.0011.873 (1.464 to 2.396)Age0.0550.01221.818<0.0011.057 (1.033 to 1.082)Pack/years0.0240.00615.695<0.0011.024 (1.012 to 1.037)ConclusionBOD, a multidimensional index of the clinical impact of COPD is valid for a 10-year prognosis and outperforms GOLD staging over that period.</description><identifier>ISSN: 0040-6376</identifier><identifier>EISSN: 1468-3296</identifier><identifier>DOI: 10.1136/thoraxjnl-2011-201054c.219</identifier><identifier>CODEN: THORA7</identifier><language>eng</language><publisher>London: BMJ Publishing Group Ltd and British Thoracic Society</publisher><ispartof>Thorax, 2011-12, Vol.66 (Suppl 4), p.A157-A157</ispartof><rights>2011, Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.</rights><rights>Copyright: 2011 (c) 2011, Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b2729-617e5216c76281161d77d95df20897d9233b817747d00196227836b7a3df09813</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://thorax.bmj.com/content/66/Suppl_4/A157.1.full.pdf$$EPDF$$P50$$Gbmj$$H</linktopdf><linktohtml>$$Uhttps://thorax.bmj.com/content/66/Suppl_4/A157.1.full$$EHTML$$P50$$Gbmj$$H</linktohtml><link.rule.ids>114,115,314,776,780,3183,23550,27901,27902,77343,77374</link.rule.ids></links><search><creatorcontrib>Keaney, N P</creatorcontrib><creatorcontrib>Ansari, K</creatorcontrib><creatorcontrib>Munby, J</creatorcontrib><creatorcontrib>Price, M</creatorcontrib><creatorcontrib>Kay, A</creatorcontrib><creatorcontrib>Taylor, I K</creatorcontrib><title>P219 Ten year mortality in a primary care COPD cohort: multidimensional index BOD more discriminant than GOLD staging</title><title>Thorax</title><addtitle>Thorax</addtitle><description>Of potential prognostic variables for COPD to use in a multidimensional staging tool, BMI, severity of airflow obstruction (FEV1% predicted) and the MRC Dyspnoea Score (BOD) have been shown to be useful for a more complete assessment of the impact of the disease.1 In 1999–2002 we identified 431 patients (208 women) with COPD in primary care surgeries and recorded their BOD scores (maximum 7). For men and women (mean±SD): age was 66±10 and 64±10; pack/years 34±19 and 34±18; BMI 27±5 and 25±6; FEV1% predicted 55±15 and 57±16; and MRC Dyspnoea Score 2.6±1.0 and 2.6±1.0; with BOD scores 1.9±1.5 and 2.0±1.6 respectively. The low mean BOD scores indicate the mainly moderate severity for this primary care cohort (only one subject had an MRC score of 5). Because of the similarities in these variables for men and women further analysis is of the whole cohort. Mortality was assessed in October 2010 and a Kaplan–Meier analysis for those with BOD scores 0 and 1 shows 80% and 75% probability of survival, whereas for a BOD score of >4 the 10-year survival was <20%. By way of contrast GOLD stages 1 and 2 had a 75% and 60% survival with Stage 4 showing a 60% survival. The Cox regression model (Abstract P219 table 1) demonstrated that BOD was a better predictor of survival than age and that smoking history was a significant covariate. Ten year survival was <10% when smoking history (with age and co-morbidity score) was added to a BOD score of >4 in a Kaplan–Meier plot.Abstract P219 Table 1Cox regression model with covariates influencing COPD mortality. (BOD quartiles: 0, 1, 2–4 and >4)BSEWald (df=1)p ValueExp (B) (95% CI)BOD quartiles0.6270.12624.889<0.0011.873 (1.464 to 2.396)Age0.0550.01221.818<0.0011.057 (1.033 to 1.082)Pack/years0.0240.00615.695<0.0011.024 (1.012 to 1.037)ConclusionBOD, a multidimensional index of the clinical impact of COPD is valid for a 10-year prognosis and outperforms GOLD staging over that period.</description><issn>0040-6376</issn><issn>1468-3296</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><recordid>eNqVkM9OAyEQh4nRxPrnHYieVxnoAutNW60m1XqoPXghdJcqdZdVoLG9efFFfRJp2nj3Mszh-80MH0InQM4AGD-Pr63Xy7mrM0oA1oXk3fKMQrGDOtDlMmO04LuoQ0iXZJwJvo8OQpgTQiSA6KDPx8T-fH2PjcMroz1uWh91beMKW4c1fve20X6FS-0N7o0e-7hs0854gZtFHW1lG-OCbZ2uE1-ZJb4a9dczDK5sKFPYOu0ijq_a4cFo2Mch6hfrXo7Q3kzXwRxv30P0dHM97t1mw9Hgrnc5zKZU0CLjIExOgZeC03Qwh0qIqsirGSWySB1lbCpBiK6oCIGCUyok41OhWTUjhQR2iE43c999-7EwIap5u_Dp3KBASJBApSCJuthQpW9D8Gamtv9WQNRatPoTrdai1Va0SvJSONuEbYhm-ZfU_k1xwUSuHiY9NRnATUHYs7pPfL7hp838P3t-ASCfk2o</recordid><startdate>201112</startdate><enddate>201112</enddate><creator>Keaney, N P</creator><creator>Ansari, K</creator><creator>Munby, J</creator><creator>Price, M</creator><creator>Kay, A</creator><creator>Taylor, I K</creator><general>BMJ Publishing Group Ltd and British Thoracic Society</general><general>BMJ Publishing Group LTD</general><scope>BSCLL</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope></search><sort><creationdate>201112</creationdate><title>P219 Ten year mortality in a primary care COPD cohort: multidimensional index BOD more discriminant than GOLD staging</title><author>Keaney, N P ; Ansari, K ; Munby, J ; Price, M ; Kay, A ; Taylor, I K</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b2729-617e5216c76281161d77d95df20897d9233b817747d00196227836b7a3df09813</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Keaney, N P</creatorcontrib><creatorcontrib>Ansari, K</creatorcontrib><creatorcontrib>Munby, J</creatorcontrib><creatorcontrib>Price, M</creatorcontrib><creatorcontrib>Kay, A</creatorcontrib><creatorcontrib>Taylor, I K</creatorcontrib><collection>Istex</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>BMJ Journals</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><jtitle>Thorax</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Keaney, N P</au><au>Ansari, K</au><au>Munby, J</au><au>Price, M</au><au>Kay, A</au><au>Taylor, I K</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>P219 Ten year mortality in a primary care COPD cohort: multidimensional index BOD more discriminant than GOLD staging</atitle><jtitle>Thorax</jtitle><addtitle>Thorax</addtitle><date>2011-12</date><risdate>2011</risdate><volume>66</volume><issue>Suppl 4</issue><spage>A157</spage><epage>A157</epage><pages>A157-A157</pages><issn>0040-6376</issn><eissn>1468-3296</eissn><coden>THORA7</coden><abstract>Of potential prognostic variables for COPD to use in a multidimensional staging tool, BMI, severity of airflow obstruction (FEV1% predicted) and the MRC Dyspnoea Score (BOD) have been shown to be useful for a more complete assessment of the impact of the disease.1 In 1999–2002 we identified 431 patients (208 women) with COPD in primary care surgeries and recorded their BOD scores (maximum 7). For men and women (mean±SD): age was 66±10 and 64±10; pack/years 34±19 and 34±18; BMI 27±5 and 25±6; FEV1% predicted 55±15 and 57±16; and MRC Dyspnoea Score 2.6±1.0 and 2.6±1.0; with BOD scores 1.9±1.5 and 2.0±1.6 respectively. The low mean BOD scores indicate the mainly moderate severity for this primary care cohort (only one subject had an MRC score of 5). Because of the similarities in these variables for men and women further analysis is of the whole cohort. Mortality was assessed in October 2010 and a Kaplan–Meier analysis for those with BOD scores 0 and 1 shows 80% and 75% probability of survival, whereas for a BOD score of >4 the 10-year survival was <20%. By way of contrast GOLD stages 1 and 2 had a 75% and 60% survival with Stage 4 showing a 60% survival. The Cox regression model (Abstract P219 table 1) demonstrated that BOD was a better predictor of survival than age and that smoking history was a significant covariate. Ten year survival was <10% when smoking history (with age and co-morbidity score) was added to a BOD score of >4 in a Kaplan–Meier plot.Abstract P219 Table 1Cox regression model with covariates influencing COPD mortality. (BOD quartiles: 0, 1, 2–4 and >4)BSEWald (df=1)p ValueExp (B) (95% CI)BOD quartiles0.6270.12624.889<0.0011.873 (1.464 to 2.396)Age0.0550.01221.818<0.0011.057 (1.033 to 1.082)Pack/years0.0240.00615.695<0.0011.024 (1.012 to 1.037)ConclusionBOD, a multidimensional index of the clinical impact of COPD is valid for a 10-year prognosis and outperforms GOLD staging over that period.</abstract><cop>London</cop><pub>BMJ Publishing Group Ltd and British Thoracic Society</pub><doi>10.1136/thoraxjnl-2011-201054c.219</doi><oa>free_for_read</oa></addata></record> |
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| title | P219 Ten year mortality in a primary care COPD cohort: multidimensional index BOD more discriminant than GOLD staging |
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