Inappropriate prescribing in elderly people with diabetes admitted to hospital
Aims To assess inappropriate prescribing in older people with diabetes mellitus during the month prior to a hospitalization, using tools on potentially inappropriate medicines (PIMs) and potential prescribing omissions (PPOs) and comparing inappropriate prescribing in patients with without diabetes....
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Veröffentlicht in: | Diabetic medicine 2016-05, Vol.33 (5), p.655-662 |
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creator | Formiga, F. Vidal, X. Agustí, A. Chivite, D. Rosón, B. Barbé, J. López-Soto, A. Torres, O. H. Fernández-Moyano, A. García, J. Ramírez-Duque, N. San José, A. |
description | Aims
To assess inappropriate prescribing in older people with diabetes mellitus during the month prior to a hospitalization, using tools on potentially inappropriate medicines (PIMs) and potential prescribing omissions (PPOs) and comparing inappropriate prescribing in patients with without diabetes.
Methods
In an observational, prospective multicentric study, we assessed inappropriate prescribing in 672 patients aged 75 years and older during hospital admission. The Beers, Screening Tool of Older Person's Prescriptions (STOPP) and Screening Tool to Alert Doctors to Right Treatment (START) criteria and Assessing Care of Vulnerable Elders (ACOVE‐3) medicine quality indicators were used. We analysed demographic and clinical factors associated with inappropriate prescribing.
Results
Of 672 patients, 249 (mean age 82.4 years, 62.9% female) had a diagnosis of diabetes mellitus. The mean number of prescribing drugs per patient with diabetes was 12.6 (4.5) vs. 9.4 (4.3) in patients without diabetes (P < 0.001). Of those patients with diabetes, 74.2% used 10 or more medications; 54.5% of patients with diabetes had at least one Beers‐listed PIM, 68.1% had at least one STOPP‐listed PIM, 64.6% had at least one START‐listed PPO and 62.8% had at least one ACOVE‐3‐listed PPO. Except for the Beers criteria, these prevalences were significantly higher in patients with diabetes than in those without. After excluding diabetes‐related items from these tools, only STOPP‐listed PIMs remained significantly higher among patients with diabetes (P = 0.04).
Conclusions
Polypharmacy is common among older patients with diabetes mellitus. Inappropriate prescribing is higher in older patients with diabetes, even when diabetes‐related treatment is excluded from the inappropriate prescribing evaluation.
What's new?
Older patients with diabetes mellitus show a higher degree of polypharmacy than those without diabetes, and three quarters of them take 10 or more drugs.
Polypharmacy places them at high risk for inappropriate prescribing.
Although polypharmacy seems difficult to avoid in such polypathological patients with diabetes, a careful review of indications, contraindications or drug–drug and drug–disease interactions should be mandatory to minimize the risk of inappropriate prescribing in these patients. |
doi_str_mv | 10.1111/dme.12894 |
format | Article |
fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_journals_1781478231</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>4025467011</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3914-264334070118a405435a995c066867f6b8064cb6b97cca3d29d31ea6fbd4b84d3</originalsourceid><addsrcrecordid>eNp1kD1PwzAQhi0EgvIx8AeQJSaGtHbs2PGIoBREKVR8jZYTX8GQNsF2VfrvCRS6ccstz7139yB0SEmXttWzU-jSNFd8A3UoFzzJuKKbqEMkTxNGJN1BuyG8EUJTxdQ22kkFY4ykooNGVzPTNL5uvDMRcOMhlN4VbvaC3QxDZcFXS9xA3VSAFy6-YutMARECNnbqYgSLY41f69C4aKp9tDUxVYCD376HHi_6D2eXyfB2cHV2OkxKpihPUsEZ40QSSnPDScZZZpTKSiJELuREFDkRvCxEoWRZGmZTZRkFIyaF5UXOLdtDx6vc9vSPOYSo3-q5n7UrNZU55TJPGW2pkxVV-joEDxPdvjk1fqkp0d_mdGtO_5hr2aPfxHkxBbsm_1S1QG8FLFwFy_-T9PlN_y8yWU24EOFzPWH8uxaSyUw_jwZ6cDe6fuL3Yz1mX1_chjs</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1781478231</pqid></control><display><type>article</type><title>Inappropriate prescribing in elderly people with diabetes admitted to hospital</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Formiga, F. ; Vidal, X. ; Agustí, A. ; Chivite, D. ; Rosón, B. ; Barbé, J. ; López-Soto, A. ; Torres, O. H. ; Fernández-Moyano, A. ; García, J. ; Ramírez-Duque, N. ; San José, A.</creator><creatorcontrib>Formiga, F. ; Vidal, X. ; Agustí, A. ; Chivite, D. ; Rosón, B. ; Barbé, J. ; López-Soto, A. ; Torres, O. H. ; Fernández-Moyano, A. ; García, J. ; Ramírez-Duque, N. ; San José, A. ; Potentially Inappropriate Prescription in Older Patients in Spain (PIPOPS) Investigators' Project</creatorcontrib><description>Aims
To assess inappropriate prescribing in older people with diabetes mellitus during the month prior to a hospitalization, using tools on potentially inappropriate medicines (PIMs) and potential prescribing omissions (PPOs) and comparing inappropriate prescribing in patients with without diabetes.
Methods
In an observational, prospective multicentric study, we assessed inappropriate prescribing in 672 patients aged 75 years and older during hospital admission. The Beers, Screening Tool of Older Person's Prescriptions (STOPP) and Screening Tool to Alert Doctors to Right Treatment (START) criteria and Assessing Care of Vulnerable Elders (ACOVE‐3) medicine quality indicators were used. We analysed demographic and clinical factors associated with inappropriate prescribing.
Results
Of 672 patients, 249 (mean age 82.4 years, 62.9% female) had a diagnosis of diabetes mellitus. The mean number of prescribing drugs per patient with diabetes was 12.6 (4.5) vs. 9.4 (4.3) in patients without diabetes (P < 0.001). Of those patients with diabetes, 74.2% used 10 or more medications; 54.5% of patients with diabetes had at least one Beers‐listed PIM, 68.1% had at least one STOPP‐listed PIM, 64.6% had at least one START‐listed PPO and 62.8% had at least one ACOVE‐3‐listed PPO. Except for the Beers criteria, these prevalences were significantly higher in patients with diabetes than in those without. After excluding diabetes‐related items from these tools, only STOPP‐listed PIMs remained significantly higher among patients with diabetes (P = 0.04).
Conclusions
Polypharmacy is common among older patients with diabetes mellitus. Inappropriate prescribing is higher in older patients with diabetes, even when diabetes‐related treatment is excluded from the inappropriate prescribing evaluation.
What's new?
Older patients with diabetes mellitus show a higher degree of polypharmacy than those without diabetes, and three quarters of them take 10 or more drugs.
Polypharmacy places them at high risk for inappropriate prescribing.
Although polypharmacy seems difficult to avoid in such polypathological patients with diabetes, a careful review of indications, contraindications or drug–drug and drug–disease interactions should be mandatory to minimize the risk of inappropriate prescribing in these patients.</description><identifier>ISSN: 0742-3071</identifier><identifier>EISSN: 1464-5491</identifier><identifier>DOI: 10.1111/dme.12894</identifier><identifier>PMID: 26333026</identifier><identifier>CODEN: DIMEEV</identifier><language>eng</language><publisher>England: Blackwell Publishing Ltd</publisher><subject>Aged ; Aged, 80 and over ; Aging ; Cohort Studies ; Comorbidity ; Developed Countries ; Diabetes ; Diabetes Complications - drug therapy ; Diabetes Complications - epidemiology ; Diabetes Mellitus, Type 2 - complications ; Diabetes Mellitus, Type 2 - drug therapy ; Diabetes Mellitus, Type 2 - epidemiology ; Electronic Health Records ; Female ; Hospitalization ; Hospitals ; Humans ; Inappropriate Prescribing ; Internal Medicine ; Male ; Medication Reconciliation ; Older people ; Polypharmacy ; Primary Health Care ; Prospective Studies ; Spain - epidemiology</subject><ispartof>Diabetic medicine, 2016-05, Vol.33 (5), p.655-662</ispartof><rights>2015 Diabetes UK</rights><rights>2015 Diabetes UK.</rights><rights>Diabetic Medicine © 2016 Diabetes UK</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3914-264334070118a405435a995c066867f6b8064cb6b97cca3d29d31ea6fbd4b84d3</citedby><cites>FETCH-LOGICAL-c3914-264334070118a405435a995c066867f6b8064cb6b97cca3d29d31ea6fbd4b84d3</cites><orcidid>0000-0002-3587-298X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fdme.12894$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fdme.12894$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26333026$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Formiga, F.</creatorcontrib><creatorcontrib>Vidal, X.</creatorcontrib><creatorcontrib>Agustí, A.</creatorcontrib><creatorcontrib>Chivite, D.</creatorcontrib><creatorcontrib>Rosón, B.</creatorcontrib><creatorcontrib>Barbé, J.</creatorcontrib><creatorcontrib>López-Soto, A.</creatorcontrib><creatorcontrib>Torres, O. H.</creatorcontrib><creatorcontrib>Fernández-Moyano, A.</creatorcontrib><creatorcontrib>García, J.</creatorcontrib><creatorcontrib>Ramírez-Duque, N.</creatorcontrib><creatorcontrib>San José, A.</creatorcontrib><creatorcontrib>Potentially Inappropriate Prescription in Older Patients in Spain (PIPOPS) Investigators' Project</creatorcontrib><title>Inappropriate prescribing in elderly people with diabetes admitted to hospital</title><title>Diabetic medicine</title><addtitle>Diabet. Med</addtitle><description>Aims
To assess inappropriate prescribing in older people with diabetes mellitus during the month prior to a hospitalization, using tools on potentially inappropriate medicines (PIMs) and potential prescribing omissions (PPOs) and comparing inappropriate prescribing in patients with without diabetes.
Methods
In an observational, prospective multicentric study, we assessed inappropriate prescribing in 672 patients aged 75 years and older during hospital admission. The Beers, Screening Tool of Older Person's Prescriptions (STOPP) and Screening Tool to Alert Doctors to Right Treatment (START) criteria and Assessing Care of Vulnerable Elders (ACOVE‐3) medicine quality indicators were used. We analysed demographic and clinical factors associated with inappropriate prescribing.
Results
Of 672 patients, 249 (mean age 82.4 years, 62.9% female) had a diagnosis of diabetes mellitus. The mean number of prescribing drugs per patient with diabetes was 12.6 (4.5) vs. 9.4 (4.3) in patients without diabetes (P < 0.001). Of those patients with diabetes, 74.2% used 10 or more medications; 54.5% of patients with diabetes had at least one Beers‐listed PIM, 68.1% had at least one STOPP‐listed PIM, 64.6% had at least one START‐listed PPO and 62.8% had at least one ACOVE‐3‐listed PPO. Except for the Beers criteria, these prevalences were significantly higher in patients with diabetes than in those without. After excluding diabetes‐related items from these tools, only STOPP‐listed PIMs remained significantly higher among patients with diabetes (P = 0.04).
Conclusions
Polypharmacy is common among older patients with diabetes mellitus. Inappropriate prescribing is higher in older patients with diabetes, even when diabetes‐related treatment is excluded from the inappropriate prescribing evaluation.
What's new?
Older patients with diabetes mellitus show a higher degree of polypharmacy than those without diabetes, and three quarters of them take 10 or more drugs.
Polypharmacy places them at high risk for inappropriate prescribing.
Although polypharmacy seems difficult to avoid in such polypathological patients with diabetes, a careful review of indications, contraindications or drug–drug and drug–disease interactions should be mandatory to minimize the risk of inappropriate prescribing in these patients.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Aging</subject><subject>Cohort Studies</subject><subject>Comorbidity</subject><subject>Developed Countries</subject><subject>Diabetes</subject><subject>Diabetes Complications - drug therapy</subject><subject>Diabetes Complications - epidemiology</subject><subject>Diabetes Mellitus, Type 2 - complications</subject><subject>Diabetes Mellitus, Type 2 - drug therapy</subject><subject>Diabetes Mellitus, Type 2 - epidemiology</subject><subject>Electronic Health Records</subject><subject>Female</subject><subject>Hospitalization</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Inappropriate Prescribing</subject><subject>Internal Medicine</subject><subject>Male</subject><subject>Medication Reconciliation</subject><subject>Older people</subject><subject>Polypharmacy</subject><subject>Primary Health Care</subject><subject>Prospective Studies</subject><subject>Spain - epidemiology</subject><issn>0742-3071</issn><issn>1464-5491</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kD1PwzAQhi0EgvIx8AeQJSaGtHbs2PGIoBREKVR8jZYTX8GQNsF2VfrvCRS6ccstz7139yB0SEmXttWzU-jSNFd8A3UoFzzJuKKbqEMkTxNGJN1BuyG8EUJTxdQ22kkFY4ykooNGVzPTNL5uvDMRcOMhlN4VbvaC3QxDZcFXS9xA3VSAFy6-YutMARECNnbqYgSLY41f69C4aKp9tDUxVYCD376HHi_6D2eXyfB2cHV2OkxKpihPUsEZ40QSSnPDScZZZpTKSiJELuREFDkRvCxEoWRZGmZTZRkFIyaF5UXOLdtDx6vc9vSPOYSo3-q5n7UrNZU55TJPGW2pkxVV-joEDxPdvjk1fqkp0d_mdGtO_5hr2aPfxHkxBbsm_1S1QG8FLFwFy_-T9PlN_y8yWU24EOFzPWH8uxaSyUw_jwZ6cDe6fuL3Yz1mX1_chjs</recordid><startdate>201605</startdate><enddate>201605</enddate><creator>Formiga, F.</creator><creator>Vidal, X.</creator><creator>Agustí, A.</creator><creator>Chivite, D.</creator><creator>Rosón, B.</creator><creator>Barbé, J.</creator><creator>López-Soto, A.</creator><creator>Torres, O. H.</creator><creator>Fernández-Moyano, A.</creator><creator>García, J.</creator><creator>Ramírez-Duque, N.</creator><creator>San José, A.</creator><general>Blackwell Publishing Ltd</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>P64</scope><scope>RC3</scope><orcidid>https://orcid.org/0000-0002-3587-298X</orcidid></search><sort><creationdate>201605</creationdate><title>Inappropriate prescribing in elderly people with diabetes admitted to hospital</title><author>Formiga, F. ; Vidal, X. ; Agustí, A. ; Chivite, D. ; Rosón, B. ; Barbé, J. ; López-Soto, A. ; Torres, O. H. ; Fernández-Moyano, A. ; García, J. ; Ramírez-Duque, N. ; San José, A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3914-264334070118a405435a995c066867f6b8064cb6b97cca3d29d31ea6fbd4b84d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Aging</topic><topic>Cohort Studies</topic><topic>Comorbidity</topic><topic>Developed Countries</topic><topic>Diabetes</topic><topic>Diabetes Complications - drug therapy</topic><topic>Diabetes Complications - epidemiology</topic><topic>Diabetes Mellitus, Type 2 - complications</topic><topic>Diabetes Mellitus, Type 2 - drug therapy</topic><topic>Diabetes Mellitus, Type 2 - epidemiology</topic><topic>Electronic Health Records</topic><topic>Female</topic><topic>Hospitalization</topic><topic>Hospitals</topic><topic>Humans</topic><topic>Inappropriate Prescribing</topic><topic>Internal Medicine</topic><topic>Male</topic><topic>Medication Reconciliation</topic><topic>Older people</topic><topic>Polypharmacy</topic><topic>Primary Health Care</topic><topic>Prospective Studies</topic><topic>Spain - epidemiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Formiga, F.</creatorcontrib><creatorcontrib>Vidal, X.</creatorcontrib><creatorcontrib>Agustí, A.</creatorcontrib><creatorcontrib>Chivite, D.</creatorcontrib><creatorcontrib>Rosón, B.</creatorcontrib><creatorcontrib>Barbé, J.</creatorcontrib><creatorcontrib>López-Soto, A.</creatorcontrib><creatorcontrib>Torres, O. H.</creatorcontrib><creatorcontrib>Fernández-Moyano, A.</creatorcontrib><creatorcontrib>García, J.</creatorcontrib><creatorcontrib>Ramírez-Duque, N.</creatorcontrib><creatorcontrib>San José, A.</creatorcontrib><creatorcontrib>Potentially Inappropriate Prescription in Older Patients in Spain (PIPOPS) Investigators' Project</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><jtitle>Diabetic medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Formiga, F.</au><au>Vidal, X.</au><au>Agustí, A.</au><au>Chivite, D.</au><au>Rosón, B.</au><au>Barbé, J.</au><au>López-Soto, A.</au><au>Torres, O. H.</au><au>Fernández-Moyano, A.</au><au>García, J.</au><au>Ramírez-Duque, N.</au><au>San José, A.</au><aucorp>Potentially Inappropriate Prescription in Older Patients in Spain (PIPOPS) Investigators' Project</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Inappropriate prescribing in elderly people with diabetes admitted to hospital</atitle><jtitle>Diabetic medicine</jtitle><addtitle>Diabet. Med</addtitle><date>2016-05</date><risdate>2016</risdate><volume>33</volume><issue>5</issue><spage>655</spage><epage>662</epage><pages>655-662</pages><issn>0742-3071</issn><eissn>1464-5491</eissn><coden>DIMEEV</coden><abstract>Aims
To assess inappropriate prescribing in older people with diabetes mellitus during the month prior to a hospitalization, using tools on potentially inappropriate medicines (PIMs) and potential prescribing omissions (PPOs) and comparing inappropriate prescribing in patients with without diabetes.
Methods
In an observational, prospective multicentric study, we assessed inappropriate prescribing in 672 patients aged 75 years and older during hospital admission. The Beers, Screening Tool of Older Person's Prescriptions (STOPP) and Screening Tool to Alert Doctors to Right Treatment (START) criteria and Assessing Care of Vulnerable Elders (ACOVE‐3) medicine quality indicators were used. We analysed demographic and clinical factors associated with inappropriate prescribing.
Results
Of 672 patients, 249 (mean age 82.4 years, 62.9% female) had a diagnosis of diabetes mellitus. The mean number of prescribing drugs per patient with diabetes was 12.6 (4.5) vs. 9.4 (4.3) in patients without diabetes (P < 0.001). Of those patients with diabetes, 74.2% used 10 or more medications; 54.5% of patients with diabetes had at least one Beers‐listed PIM, 68.1% had at least one STOPP‐listed PIM, 64.6% had at least one START‐listed PPO and 62.8% had at least one ACOVE‐3‐listed PPO. Except for the Beers criteria, these prevalences were significantly higher in patients with diabetes than in those without. After excluding diabetes‐related items from these tools, only STOPP‐listed PIMs remained significantly higher among patients with diabetes (P = 0.04).
Conclusions
Polypharmacy is common among older patients with diabetes mellitus. Inappropriate prescribing is higher in older patients with diabetes, even when diabetes‐related treatment is excluded from the inappropriate prescribing evaluation.
What's new?
Older patients with diabetes mellitus show a higher degree of polypharmacy than those without diabetes, and three quarters of them take 10 or more drugs.
Polypharmacy places them at high risk for inappropriate prescribing.
Although polypharmacy seems difficult to avoid in such polypathological patients with diabetes, a careful review of indications, contraindications or drug–drug and drug–disease interactions should be mandatory to minimize the risk of inappropriate prescribing in these patients.</abstract><cop>England</cop><pub>Blackwell Publishing Ltd</pub><pmid>26333026</pmid><doi>10.1111/dme.12894</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-3587-298X</orcidid></addata></record> |
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subjects | Aged Aged, 80 and over Aging Cohort Studies Comorbidity Developed Countries Diabetes Diabetes Complications - drug therapy Diabetes Complications - epidemiology Diabetes Mellitus, Type 2 - complications Diabetes Mellitus, Type 2 - drug therapy Diabetes Mellitus, Type 2 - epidemiology Electronic Health Records Female Hospitalization Hospitals Humans Inappropriate Prescribing Internal Medicine Male Medication Reconciliation Older people Polypharmacy Primary Health Care Prospective Studies Spain - epidemiology |
title | Inappropriate prescribing in elderly people with diabetes admitted to hospital |
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