Excess of mesotheliomas after exposure to chrysotile in Balangero, Italy
Background: Chrysotile from the mine in Balangero, Italy is considered to be free of tremolite. In a cohort study of miners and millers only two pleural cancers were reported, a finding considered to indicate that chrysotile has a low potency for inducing mesothelioma. However, follow-up ended in 19...
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| Veröffentlicht in: | Occupational and environmental medicine (London, England) England), 2008-12, Vol.65 (12), p.815-819 |
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| creator | Mirabelli, D Calisti, R Barone-Adesi, F Fornero, E Merletti, F Magnani, C |
| description | Background: Chrysotile from the mine in Balangero, Italy is considered to be free of tremolite. In a cohort study of miners and millers only two pleural cancers were reported, a finding considered to indicate that chrysotile has a low potency for inducing mesothelioma. However, follow-up ended in 1987 and white-collar workers and the employees of subcontractors were not studied. Methods: To complete the case ascertainment, the study searched the Registry of Malignant Mesotheliomas of Piedmont for records of cases of pleural mesothelioma among the following: mine employees; employees of subcontractors or of other firms transporting or refining Balangero asbestos, asbestos ore or mine tailings; individuals exposed to air pollution from the mine or living with mine employees; and individuals exposed to mine tailings from Balangero. Results: The study identified four new cases of pleural mesothelioma among blue-collar workers in the mine, in addition to the two reported in the cohort study. Thus, six mesotheliomas occurred, compared to the 1.5 expected (p |
| doi_str_mv | 10.1136/oem.2007.037689 |
| format | Article |
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In a cohort study of miners and millers only two pleural cancers were reported, a finding considered to indicate that chrysotile has a low potency for inducing mesothelioma. However, follow-up ended in 1987 and white-collar workers and the employees of subcontractors were not studied. Methods: To complete the case ascertainment, the study searched the Registry of Malignant Mesotheliomas of Piedmont for records of cases of pleural mesothelioma among the following: mine employees; employees of subcontractors or of other firms transporting or refining Balangero asbestos, asbestos ore or mine tailings; individuals exposed to air pollution from the mine or living with mine employees; and individuals exposed to mine tailings from Balangero. Results: The study identified four new cases of pleural mesothelioma among blue-collar workers in the mine, in addition to the two reported in the cohort study. Thus, six mesotheliomas occurred, compared to the 1.5 expected (p<0.01). The study also identified three mesothelioma cases among white-collar employees at the mine, five in workers in the mine hired by subcontracting firms, and three among workers processing Balangero chrysotile outside the mine. Finally, 10 additional cases due to non-occupational exposure or exposure to re-used mine tailings were identified. Conclusions: The cluster of 14 mesothelioma cases among workers who were active in the mine and 13 among other people exposed to Balangero chrysotile provides further evidence that tremolite-free chrysotile is carcinogenic.</description><identifier>ISSN: 1351-0711</identifier><identifier>EISSN: 1470-7926</identifier><identifier>DOI: 10.1136/oem.2007.037689</identifier><identifier>PMID: 18524838</identifier><language>eng</language><publisher>London: BMJ Publishing Group Ltd</publisher><subject>Aged ; Air pollution ; Asbestos ; Asbestos mining ; Asbestos, Serpentine - adverse effects ; Biological and medical sciences ; Chemical and industrial products toxicology. Toxic occupational diseases ; Employees ; Humans ; Inorganic dusts (pneumoconiosises) and organic dusts (byssinosis etc.) ; Italy - epidemiology ; Male ; Manual labor ; Manual workers ; Medical sciences ; Mesothelioma ; Mesothelioma - epidemiology ; Mesothelioma - etiology ; Middle Aged ; Mine tailings ; Mine waste ; Mine wastes ; Mining ; Mortality ; Occupational Diseases - epidemiology ; Occupational Diseases - etiology ; Occupational exposure ; Occupational Exposure - adverse effects ; Occupational Exposure - analysis ; Pleural Neoplasms - epidemiology ; Pleural Neoplasms - etiology ; Railroad track components ; Subcontractors ; Tailings ; Toxicology</subject><ispartof>Occupational and environmental medicine (London, England), 2008-12, Vol.65 (12), p.815-819</ispartof><rights>2008 BMJ Publishing Group</rights><rights>2009 INIST-CNRS</rights><rights>Copyright: 2008 2008 BMJ Publishing Group</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b448t-4216b03c3a465b4e9fbf509ff9dfbb7e42247d46f5be90e60a6ebe58c4ef1d6d3</citedby><cites>FETCH-LOGICAL-b448t-4216b03c3a465b4e9fbf509ff9dfbb7e42247d46f5be90e60a6ebe58c4ef1d6d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://oem.bmj.com/content/65/12/815.full.pdf$$EPDF$$P50$$Gbmj$$H</linktopdf><linktohtml>$$Uhttps://oem.bmj.com/content/65/12/815.full$$EHTML$$P50$$Gbmj$$H</linktohtml><link.rule.ids>114,115,314,780,784,803,3196,23571,27924,27925,58017,58250,77600,77631</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20833636$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18524838$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mirabelli, D</creatorcontrib><creatorcontrib>Calisti, R</creatorcontrib><creatorcontrib>Barone-Adesi, F</creatorcontrib><creatorcontrib>Fornero, E</creatorcontrib><creatorcontrib>Merletti, F</creatorcontrib><creatorcontrib>Magnani, C</creatorcontrib><title>Excess of mesotheliomas after exposure to chrysotile in Balangero, Italy</title><title>Occupational and environmental medicine (London, England)</title><addtitle>Occup Environ Med</addtitle><description>Background: Chrysotile from the mine in Balangero, Italy is considered to be free of tremolite. In a cohort study of miners and millers only two pleural cancers were reported, a finding considered to indicate that chrysotile has a low potency for inducing mesothelioma. However, follow-up ended in 1987 and white-collar workers and the employees of subcontractors were not studied. Methods: To complete the case ascertainment, the study searched the Registry of Malignant Mesotheliomas of Piedmont for records of cases of pleural mesothelioma among the following: mine employees; employees of subcontractors or of other firms transporting or refining Balangero asbestos, asbestos ore or mine tailings; individuals exposed to air pollution from the mine or living with mine employees; and individuals exposed to mine tailings from Balangero. Results: The study identified four new cases of pleural mesothelioma among blue-collar workers in the mine, in addition to the two reported in the cohort study. Thus, six mesotheliomas occurred, compared to the 1.5 expected (p<0.01). The study also identified three mesothelioma cases among white-collar employees at the mine, five in workers in the mine hired by subcontracting firms, and three among workers processing Balangero chrysotile outside the mine. Finally, 10 additional cases due to non-occupational exposure or exposure to re-used mine tailings were identified. Conclusions: The cluster of 14 mesothelioma cases among workers who were active in the mine and 13 among other people exposed to Balangero chrysotile provides further evidence that tremolite-free chrysotile is carcinogenic.</description><subject>Aged</subject><subject>Air pollution</subject><subject>Asbestos</subject><subject>Asbestos mining</subject><subject>Asbestos, Serpentine - adverse effects</subject><subject>Biological and medical sciences</subject><subject>Chemical and industrial products toxicology. 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Toxic occupational diseases</topic><topic>Employees</topic><topic>Humans</topic><topic>Inorganic dusts (pneumoconiosises) and organic dusts (byssinosis etc.)</topic><topic>Italy - epidemiology</topic><topic>Male</topic><topic>Manual labor</topic><topic>Manual workers</topic><topic>Medical sciences</topic><topic>Mesothelioma</topic><topic>Mesothelioma - epidemiology</topic><topic>Mesothelioma - etiology</topic><topic>Middle Aged</topic><topic>Mine tailings</topic><topic>Mine waste</topic><topic>Mine wastes</topic><topic>Mining</topic><topic>Mortality</topic><topic>Occupational Diseases - epidemiology</topic><topic>Occupational Diseases - etiology</topic><topic>Occupational exposure</topic><topic>Occupational Exposure - adverse effects</topic><topic>Occupational Exposure - analysis</topic><topic>Pleural Neoplasms - epidemiology</topic><topic>Pleural Neoplasms - etiology</topic><topic>Railroad track components</topic><topic>Subcontractors</topic><topic>Tailings</topic><topic>Toxicology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mirabelli, D</creatorcontrib><creatorcontrib>Calisti, R</creatorcontrib><creatorcontrib>Barone-Adesi, F</creatorcontrib><creatorcontrib>Fornero, E</creatorcontrib><creatorcontrib>Merletti, F</creatorcontrib><creatorcontrib>Magnani, C</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>BMJ Journals</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Engineering Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Engineering Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Environmental Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>Engineering Collection</collection><collection>Environmental Science Collection</collection><jtitle>Occupational and environmental medicine (London, England)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mirabelli, D</au><au>Calisti, R</au><au>Barone-Adesi, F</au><au>Fornero, E</au><au>Merletti, F</au><au>Magnani, C</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Excess of mesotheliomas after exposure to chrysotile in Balangero, Italy</atitle><jtitle>Occupational and environmental medicine (London, England)</jtitle><addtitle>Occup Environ Med</addtitle><date>2008-12-01</date><risdate>2008</risdate><volume>65</volume><issue>12</issue><spage>815</spage><epage>819</epage><pages>815-819</pages><issn>1351-0711</issn><eissn>1470-7926</eissn><abstract>Background: Chrysotile from the mine in Balangero, Italy is considered to be free of tremolite. In a cohort study of miners and millers only two pleural cancers were reported, a finding considered to indicate that chrysotile has a low potency for inducing mesothelioma. However, follow-up ended in 1987 and white-collar workers and the employees of subcontractors were not studied. Methods: To complete the case ascertainment, the study searched the Registry of Malignant Mesotheliomas of Piedmont for records of cases of pleural mesothelioma among the following: mine employees; employees of subcontractors or of other firms transporting or refining Balangero asbestos, asbestos ore or mine tailings; individuals exposed to air pollution from the mine or living with mine employees; and individuals exposed to mine tailings from Balangero. Results: The study identified four new cases of pleural mesothelioma among blue-collar workers in the mine, in addition to the two reported in the cohort study. Thus, six mesotheliomas occurred, compared to the 1.5 expected (p<0.01). The study also identified three mesothelioma cases among white-collar employees at the mine, five in workers in the mine hired by subcontracting firms, and three among workers processing Balangero chrysotile outside the mine. Finally, 10 additional cases due to non-occupational exposure or exposure to re-used mine tailings were identified. Conclusions: The cluster of 14 mesothelioma cases among workers who were active in the mine and 13 among other people exposed to Balangero chrysotile provides further evidence that tremolite-free chrysotile is carcinogenic.</abstract><cop>London</cop><pub>BMJ Publishing Group Ltd</pub><pmid>18524838</pmid><doi>10.1136/oem.2007.037689</doi><tpages>5</tpages></addata></record> |
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| subjects | Aged Air pollution Asbestos Asbestos mining Asbestos, Serpentine - adverse effects Biological and medical sciences Chemical and industrial products toxicology. Toxic occupational diseases Employees Humans Inorganic dusts (pneumoconiosises) and organic dusts (byssinosis etc.) Italy - epidemiology Male Manual labor Manual workers Medical sciences Mesothelioma Mesothelioma - epidemiology Mesothelioma - etiology Middle Aged Mine tailings Mine waste Mine wastes Mining Mortality Occupational Diseases - epidemiology Occupational Diseases - etiology Occupational exposure Occupational Exposure - adverse effects Occupational Exposure - analysis Pleural Neoplasms - epidemiology Pleural Neoplasms - etiology Railroad track components Subcontractors Tailings Toxicology |
| title | Excess of mesotheliomas after exposure to chrysotile in Balangero, Italy |
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