C05 TP53 R72P polymorphism as a modifier of age at onset of Huntington's disease

Background The size of the CAG repeat tract is the major determinant of age of onset (AO) in Huntington's disease (HD). However, the number of the CAG repeats does not allow an accurate prediction of AO; only 30–70% of the variance in AO can be explained by the repeat size alone. R72P polymorph...

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Veröffentlicht in:	Journal of neurology, neurosurgery and psychiatry neurosurgery and psychiatry, 2010-09, Vol.81 (Suppl 1), p.A17-A17
Hauptverfasser:	Tunali, N E, Acar-Hazer, A, Erginel-Unaltuna, N, Hanagasi, H A
Format:	Artikel
Sprache:	eng
Schlagworte:	age at onset R72P TP53
Online-Zugang:	Volltext
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