Association between apolipoprotein- 4 and long-term outcome after traumatic brain injury
Objectives: To investigate the effect of carrying the apolipoprotein epsilon 4 (APOE-â^S4) allele on global functional outcome, on activity limitations and participation restrictions, and on community integration at 3, 6, 12, 18, 24 and 36 months after traumatic brain injury. Method: The Glasgow Out...
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| Veröffentlicht in: | Journal of neurology, neurosurgery and psychiatry neurosurgery and psychiatry, 2008-04, Vol.79 (4), p.426-430 |
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| container_title | Journal of neurology, neurosurgery and psychiatry |
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| creator | Son, A H P W.-v. Ribbers, G M Hop, W C J van Duijn, C M Stam, H J |
| description | Objectives: To investigate the effect of carrying the apolipoprotein epsilon 4 (APOE-â^S4) allele on global functional outcome, on activity limitations and participation restrictions, and on community integration at 3, 6, 12, 18, 24 and 36 months after traumatic brain injury. Method: The Glasgow Outcome Scale (GOS), the Sickness Impact Profile-68 (SIP-68) and the Community Integration Questionnaire (CIQ) were assessed in 79 moderate and severe traumatic brain injury patients at 3, 6, 12, 18, 24 and 36 months post injury. Repeated measures analyses of variance were performed with APOE-â^S4 status and time of measurement as independent variables and the GOS, SIP-68 and CIQ as dependent variables. Analyses were adjusted for baseline age, gender and Glasgow Coma Scale. Results: Patients with the APOE-â^S4 allele had a significantly better global functional outcome on the GOS than patients without the APOE-â^S4 allele. No significant associations were found between APOE-â^S4 status and the SIP-68 and CIQ. Discussion: In contrast to other studies, we found that carrying the APOE-â^S4 allele had a protective influence on outcome. Multiple mechanisms, and in some cases competitive mechanisms, may explain the variable relation between the APOE-â^S4 allele and outcome after traumatic brain injury. |
| doi_str_mv | 10.1136/jnnp.2007.129460 |
| format | Article |
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Method: The Glasgow Outcome Scale (GOS), the Sickness Impact Profile-68 (SIP-68) and the Community Integration Questionnaire (CIQ) were assessed in 79 moderate and severe traumatic brain injury patients at 3, 6, 12, 18, 24 and 36 months post injury. Repeated measures analyses of variance were performed with APOE-â^S4 status and time of measurement as independent variables and the GOS, SIP-68 and CIQ as dependent variables. Analyses were adjusted for baseline age, gender and Glasgow Coma Scale. Results: Patients with the APOE-â^S4 allele had a significantly better global functional outcome on the GOS than patients without the APOE-â^S4 allele. No significant associations were found between APOE-â^S4 status and the SIP-68 and CIQ. Discussion: In contrast to other studies, we found that carrying the APOE-â^S4 allele had a protective influence on outcome. Multiple mechanisms, and in some cases competitive mechanisms, may explain the variable relation between the APOE-â^S4 allele and outcome after traumatic brain injury.</description><identifier>ISSN: 0022-3050</identifier><identifier>EISSN: 1468-330X</identifier><identifier>DOI: 10.1136/jnnp.2007.129460</identifier><identifier>CODEN: JNNPAU</identifier><language>eng</language><publisher>London: BMJ Publishing Group LTD</publisher><subject>Apolipoproteins ; Deoxyribonucleic acid ; DNA ; Education ; Genetic testing ; Hospitals ; Morbidity ; Mortality ; Neurogenesis ; Studies ; Traumatic brain injury ; Variables ; Variance analysis</subject><ispartof>Journal of neurology, neurosurgery and psychiatry, 2008-04, Vol.79 (4), p.426-430</ispartof><rights>Copyright: 2008 2008 BMJ Publishing Group</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c1161-7fd932f1ba7ebde3003c02c9c01af6cdf249ea64351d172b73ac64f04c6c75a3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,3182,27903,27904</link.rule.ids></links><search><creatorcontrib>Son, A H P W.-v.</creatorcontrib><creatorcontrib>Ribbers, G M</creatorcontrib><creatorcontrib>Hop, W C J</creatorcontrib><creatorcontrib>van Duijn, C M</creatorcontrib><creatorcontrib>Stam, H J</creatorcontrib><title>Association between apolipoprotein- 4 and long-term outcome after traumatic brain injury</title><title>Journal of neurology, neurosurgery and psychiatry</title><description>Objectives: To investigate the effect of carrying the apolipoprotein epsilon 4 (APOE-â^S4) allele on global functional outcome, on activity limitations and participation restrictions, and on community integration at 3, 6, 12, 18, 24 and 36 months after traumatic brain injury. Method: The Glasgow Outcome Scale (GOS), the Sickness Impact Profile-68 (SIP-68) and the Community Integration Questionnaire (CIQ) were assessed in 79 moderate and severe traumatic brain injury patients at 3, 6, 12, 18, 24 and 36 months post injury. Repeated measures analyses of variance were performed with APOE-â^S4 status and time of measurement as independent variables and the GOS, SIP-68 and CIQ as dependent variables. Analyses were adjusted for baseline age, gender and Glasgow Coma Scale. Results: Patients with the APOE-â^S4 allele had a significantly better global functional outcome on the GOS than patients without the APOE-â^S4 allele. No significant associations were found between APOE-â^S4 status and the SIP-68 and CIQ. Discussion: In contrast to other studies, we found that carrying the APOE-â^S4 allele had a protective influence on outcome. Multiple mechanisms, and in some cases competitive mechanisms, may explain the variable relation between the APOE-â^S4 allele and outcome after traumatic brain injury.</description><subject>Apolipoproteins</subject><subject>Deoxyribonucleic acid</subject><subject>DNA</subject><subject>Education</subject><subject>Genetic testing</subject><subject>Hospitals</subject><subject>Morbidity</subject><subject>Mortality</subject><subject>Neurogenesis</subject><subject>Studies</subject><subject>Traumatic brain injury</subject><subject>Variables</subject><subject>Variance analysis</subject><issn>0022-3050</issn><issn>1468-330X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNotkM1KxDAUhYMoOI7uXQZcd7w3SdN2OQz-wYCbWegqpGkiLdOkJi3i2_gsPpkt490cLhzOOXyE3CJsELm877wfNgyg2CCrhIQzskIhy4xzeDsnKwDGMg45XJKrlDpYrqxW5H2bUjCtHtvgaW3HL2s91UM4tkMYYhht67PfH0G1b-gx-I9stLGnYRpN6C3Vbn7pGPXUzwmG1lG3nra-m-L3Nblw-pjszb-uyeHx4bB7zvavTy-77T4ziBKzwjUVZw5rXdi6sRyAG2CmMoDaSdM4JiqrpeA5NliwuuDaSOFAGGmKXPM1uTvFzms_J5tG1YUp-rlRYVEiE6zMcXbByWViSClap4bY9jp-KwS18FMLP7XwUyd-_A-Aq2YH</recordid><startdate>20080401</startdate><enddate>20080401</enddate><creator>Son, A H P W.-v.</creator><creator>Ribbers, G M</creator><creator>Hop, W C J</creator><creator>van Duijn, C M</creator><creator>Stam, H J</creator><general>BMJ Publishing Group LTD</general><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>88I</scope><scope>8AF</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>M2P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope></search><sort><creationdate>20080401</creationdate><title>Association between apolipoprotein- 4 and long-term outcome after traumatic brain injury</title><author>Son, A H P W.-v. ; Ribbers, G M ; Hop, W C J ; van Duijn, C M ; Stam, H J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c1161-7fd932f1ba7ebde3003c02c9c01af6cdf249ea64351d172b73ac64f04c6c75a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Apolipoproteins</topic><topic>Deoxyribonucleic acid</topic><topic>DNA</topic><topic>Education</topic><topic>Genetic testing</topic><topic>Hospitals</topic><topic>Morbidity</topic><topic>Mortality</topic><topic>Neurogenesis</topic><topic>Studies</topic><topic>Traumatic brain injury</topic><topic>Variables</topic><topic>Variance analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Son, A H P W.-v.</creatorcontrib><creatorcontrib>Ribbers, G M</creatorcontrib><creatorcontrib>Hop, W C J</creatorcontrib><creatorcontrib>van Duijn, C M</creatorcontrib><creatorcontrib>Stam, H J</creatorcontrib><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>BMJ Journals</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest Psychology</collection><collection>Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><jtitle>Journal of neurology, neurosurgery and psychiatry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Son, A H P W.-v.</au><au>Ribbers, G M</au><au>Hop, W C J</au><au>van Duijn, C M</au><au>Stam, H J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association between apolipoprotein- 4 and long-term outcome after traumatic brain injury</atitle><jtitle>Journal of neurology, neurosurgery and psychiatry</jtitle><date>2008-04-01</date><risdate>2008</risdate><volume>79</volume><issue>4</issue><spage>426</spage><epage>430</epage><pages>426-430</pages><issn>0022-3050</issn><eissn>1468-330X</eissn><coden>JNNPAU</coden><abstract>Objectives: To investigate the effect of carrying the apolipoprotein epsilon 4 (APOE-â^S4) allele on global functional outcome, on activity limitations and participation restrictions, and on community integration at 3, 6, 12, 18, 24 and 36 months after traumatic brain injury. Method: The Glasgow Outcome Scale (GOS), the Sickness Impact Profile-68 (SIP-68) and the Community Integration Questionnaire (CIQ) were assessed in 79 moderate and severe traumatic brain injury patients at 3, 6, 12, 18, 24 and 36 months post injury. Repeated measures analyses of variance were performed with APOE-â^S4 status and time of measurement as independent variables and the GOS, SIP-68 and CIQ as dependent variables. Analyses were adjusted for baseline age, gender and Glasgow Coma Scale. Results: Patients with the APOE-â^S4 allele had a significantly better global functional outcome on the GOS than patients without the APOE-â^S4 allele. No significant associations were found between APOE-â^S4 status and the SIP-68 and CIQ. Discussion: In contrast to other studies, we found that carrying the APOE-â^S4 allele had a protective influence on outcome. Multiple mechanisms, and in some cases competitive mechanisms, may explain the variable relation between the APOE-â^S4 allele and outcome after traumatic brain injury.</abstract><cop>London</cop><pub>BMJ Publishing Group LTD</pub><doi>10.1136/jnnp.2007.129460</doi><tpages>5</tpages></addata></record> |
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| subjects | Apolipoproteins Deoxyribonucleic acid DNA Education Genetic testing Hospitals Morbidity Mortality Neurogenesis Studies Traumatic brain injury Variables Variance analysis |
| title | Association between apolipoprotein- 4 and long-term outcome after traumatic brain injury |
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