novel method for the determination of three volatile organic compounds in exhaled breath by solid-phase microextraction–ion mobility spectrometry
A method was carried out for the quantitative determination of the concentrations of volatile organic compounds (VOCs) using solid-phase microextraction and ion mobility spectrometry (SPME–IMS). This method was optimized and evaluated. The best results were obtained at sorption temperature 70 °C, de...
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| Veröffentlicht in: | Analytical and bioanalytical chemistry 2016-01, Vol.408 (3), p.839-847 |
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| creator | Allafchian, Ali Reza Majidian, Zahra Ielbeigi, Vahideh Tabrizchi, Mahmoud |
| description | A method was carried out for the quantitative determination of the concentrations of volatile organic compounds (VOCs) using solid-phase microextraction and ion mobility spectrometry (SPME–IMS). This method was optimized and evaluated. The best results were obtained at sorption temperature 70 °C, desorption temperature 200 °C, and extraction time 15 min. Under the optimized conditions, the linear dynamic range was found to be 0.01–4.0 ppb (R ² > 0.995), 2.3–400 ppm (R ² > 0.994), and 2.5–76 ppb (R ² > 0.998) for acetone, acetaldehyde, and acetonitrile, respectively. The detection limits for acetone, acetaldehyde, and acetonitrile were 0.001 ppb, 0.18 ppm, and 0.22 ppb, respectively. As a practical application, the method was applied for the determination of acetone, acetaldehyde, and acetonitrile in human breath matrix. Therefore, the proposed method was found to be effective and simple enough to be strongly recommended for real sample analysis. |
| doi_str_mv | 10.1007/s00216-015-9170-8 |
| format | Article |
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This method was optimized and evaluated. The best results were obtained at sorption temperature 70 °C, desorption temperature 200 °C, and extraction time 15 min. Under the optimized conditions, the linear dynamic range was found to be 0.01–4.0 ppb (R ² > 0.995), 2.3–400 ppm (R ² > 0.994), and 2.5–76 ppb (R ² > 0.998) for acetone, acetaldehyde, and acetonitrile, respectively. The detection limits for acetone, acetaldehyde, and acetonitrile were 0.001 ppb, 0.18 ppm, and 0.22 ppb, respectively. As a practical application, the method was applied for the determination of acetone, acetaldehyde, and acetonitrile in human breath matrix. Therefore, the proposed method was found to be effective and simple enough to be strongly recommended for real sample analysis.</description><identifier>ISSN: 1618-2642</identifier><identifier>EISSN: 1618-2650</identifier><identifier>DOI: 10.1007/s00216-015-9170-8</identifier><identifier>PMID: 26558761</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>acetaldehyde ; Acetone ; acetonitrile ; Adult ; Analytical Chemistry ; Biochemistry ; Biofilms ; Breath tests ; Breath Tests - methods ; Characterization and Evaluation of Materials ; Chemical properties ; Chemistry ; Chemistry and Materials Science ; Chromatography ; desorption ; detection limit ; Detection limits ; Extraction (Chemistry) ; Female ; Food Science ; Fourier transforms ; Fractionation ; Humans ; Identification and classification ; Laboratory Medicine ; Lung cancer ; Mass Spectrometry - methods ; Methods ; Monitoring/Environmental Analysis ; Nanomaterials ; Nanoparticles ; Organic compounds ; quantitative analysis ; Research Paper ; Scientific imaging ; solid phase microextraction ; Solid Phase Microextraction - methods ; Spectrometry ; Spectroscopy ; temperature ; VOCs ; Volatile organic compounds ; Volatile Organic Compounds - chemistry ; Volatile Organic Compounds - isolation & purification</subject><ispartof>Analytical and bioanalytical chemistry, 2016-01, Vol.408 (3), p.839-847</ispartof><rights>Springer-Verlag Berlin Heidelberg 2015</rights><rights>COPYRIGHT 2016 Springer</rights><rights>Springer-Verlag Berlin Heidelberg 2016</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c509t-39b892c36bc9e19d60269f35a77079f208fed6189073ddb70c3c624dcc3e68973</citedby><cites>FETCH-LOGICAL-c509t-39b892c36bc9e19d60269f35a77079f208fed6189073ddb70c3c624dcc3e68973</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00216-015-9170-8$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00216-015-9170-8$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26558761$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Allafchian, Ali Reza</creatorcontrib><creatorcontrib>Majidian, Zahra</creatorcontrib><creatorcontrib>Ielbeigi, Vahideh</creatorcontrib><creatorcontrib>Tabrizchi, Mahmoud</creatorcontrib><title>novel method for the determination of three volatile organic compounds in exhaled breath by solid-phase microextraction–ion mobility spectrometry</title><title>Analytical and bioanalytical chemistry</title><addtitle>Anal Bioanal Chem</addtitle><addtitle>Anal Bioanal Chem</addtitle><description>A method was carried out for the quantitative determination of the concentrations of volatile organic compounds (VOCs) using solid-phase microextraction and ion mobility spectrometry (SPME–IMS). This method was optimized and evaluated. The best results were obtained at sorption temperature 70 °C, desorption temperature 200 °C, and extraction time 15 min. Under the optimized conditions, the linear dynamic range was found to be 0.01–4.0 ppb (R ² > 0.995), 2.3–400 ppm (R ² > 0.994), and 2.5–76 ppb (R ² > 0.998) for acetone, acetaldehyde, and acetonitrile, respectively. The detection limits for acetone, acetaldehyde, and acetonitrile were 0.001 ppb, 0.18 ppm, and 0.22 ppb, respectively. As a practical application, the method was applied for the determination of acetone, acetaldehyde, and acetonitrile in human breath matrix. Therefore, the proposed method was found to be effective and simple enough to be strongly recommended for real sample analysis.</description><subject>acetaldehyde</subject><subject>Acetone</subject><subject>acetonitrile</subject><subject>Adult</subject><subject>Analytical Chemistry</subject><subject>Biochemistry</subject><subject>Biofilms</subject><subject>Breath tests</subject><subject>Breath Tests - methods</subject><subject>Characterization and Evaluation of Materials</subject><subject>Chemical properties</subject><subject>Chemistry</subject><subject>Chemistry and Materials Science</subject><subject>Chromatography</subject><subject>desorption</subject><subject>detection limit</subject><subject>Detection limits</subject><subject>Extraction (Chemistry)</subject><subject>Female</subject><subject>Food Science</subject><subject>Fourier transforms</subject><subject>Fractionation</subject><subject>Humans</subject><subject>Identification and classification</subject><subject>Laboratory Medicine</subject><subject>Lung cancer</subject><subject>Mass Spectrometry - methods</subject><subject>Methods</subject><subject>Monitoring/Environmental Analysis</subject><subject>Nanomaterials</subject><subject>Nanoparticles</subject><subject>Organic compounds</subject><subject>quantitative analysis</subject><subject>Research Paper</subject><subject>Scientific imaging</subject><subject>solid phase microextraction</subject><subject>Solid Phase Microextraction - methods</subject><subject>Spectrometry</subject><subject>Spectroscopy</subject><subject>temperature</subject><subject>VOCs</subject><subject>Volatile organic compounds</subject><subject>Volatile Organic Compounds - chemistry</subject><subject>Volatile Organic Compounds - isolation & 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method for the determination of three volatile organic compounds in exhaled breath by solid-phase microextraction–ion mobility spectrometry</title><author>Allafchian, Ali Reza ; Majidian, Zahra ; Ielbeigi, Vahideh ; Tabrizchi, Mahmoud</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c509t-39b892c36bc9e19d60269f35a77079f208fed6189073ddb70c3c624dcc3e68973</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>acetaldehyde</topic><topic>Acetone</topic><topic>acetonitrile</topic><topic>Adult</topic><topic>Analytical Chemistry</topic><topic>Biochemistry</topic><topic>Biofilms</topic><topic>Breath tests</topic><topic>Breath Tests - methods</topic><topic>Characterization and Evaluation of Materials</topic><topic>Chemical properties</topic><topic>Chemistry</topic><topic>Chemistry and Materials Science</topic><topic>Chromatography</topic><topic>desorption</topic><topic>detection 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Academic</collection><collection>ProQuest One Academic UKI Edition</collection><jtitle>Analytical and bioanalytical chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Allafchian, Ali Reza</au><au>Majidian, Zahra</au><au>Ielbeigi, Vahideh</au><au>Tabrizchi, Mahmoud</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>novel method for the determination of three volatile organic compounds in exhaled breath by solid-phase microextraction–ion mobility spectrometry</atitle><jtitle>Analytical and bioanalytical chemistry</jtitle><stitle>Anal Bioanal Chem</stitle><addtitle>Anal Bioanal Chem</addtitle><date>2016-01-01</date><risdate>2016</risdate><volume>408</volume><issue>3</issue><spage>839</spage><epage>847</epage><pages>839-847</pages><issn>1618-2642</issn><eissn>1618-2650</eissn><abstract>A method was carried out for the quantitative determination of the concentrations of volatile organic compounds (VOCs) using solid-phase microextraction and ion mobility spectrometry (SPME–IMS). This method was optimized and evaluated. The best results were obtained at sorption temperature 70 °C, desorption temperature 200 °C, and extraction time 15 min. Under the optimized conditions, the linear dynamic range was found to be 0.01–4.0 ppb (R ² > 0.995), 2.3–400 ppm (R ² > 0.994), and 2.5–76 ppb (R ² > 0.998) for acetone, acetaldehyde, and acetonitrile, respectively. The detection limits for acetone, acetaldehyde, and acetonitrile were 0.001 ppb, 0.18 ppm, and 0.22 ppb, respectively. As a practical application, the method was applied for the determination of acetone, acetaldehyde, and acetonitrile in human breath matrix. Therefore, the proposed method was found to be effective and simple enough to be strongly recommended for real sample analysis.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>26558761</pmid><doi>10.1007/s00216-015-9170-8</doi><tpages>9</tpages></addata></record> |
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| subjects | acetaldehyde Acetone acetonitrile Adult Analytical Chemistry Biochemistry Biofilms Breath tests Breath Tests - methods Characterization and Evaluation of Materials Chemical properties Chemistry Chemistry and Materials Science Chromatography desorption detection limit Detection limits Extraction (Chemistry) Female Food Science Fourier transforms Fractionation Humans Identification and classification Laboratory Medicine Lung cancer Mass Spectrometry - methods Methods Monitoring/Environmental Analysis Nanomaterials Nanoparticles Organic compounds quantitative analysis Research Paper Scientific imaging solid phase microextraction Solid Phase Microextraction - methods Spectrometry Spectroscopy temperature VOCs Volatile organic compounds Volatile Organic Compounds - chemistry Volatile Organic Compounds - isolation & purification |
| title | novel method for the determination of three volatile organic compounds in exhaled breath by solid-phase microextraction–ion mobility spectrometry |
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