A functional variant in TP63 at 3q28 associated with bladder cancer risk by creating an miR‐140‐5p binding site

The first genome‐wide association study (GWAS) for bladder cancer has identified a susceptibility locus at 3q28 in the European ancestry. However, the causal variant at 3q28 remains unknown. We conducted a three‐stage fine mapping study to identify potential causal variants in the region. A total of...

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Veröffentlicht in:	International journal of cancer 2016-07, Vol.139 (1), p.65-74
Hauptverfasser:	Wang, Meilin, Du, Mulong, Ma, Lan, Chu, Haiyan, Lv, Qiang, Ye, Dingwei, Guo, Jianming, Gu, Chengyuan, Xia, Guowei, Zhu, Yao, Ding, Qiang, Yuan, Lin, Fu, Guangbo, Tong, Na, Qin, Chao, Yin, Changjun, Xu, Jianfeng, Zhang, Zhengdong
Format:	Artikel
Sprache:	eng
Schlagworte:	3q28 Adult Aged Alleles Binding Sites Bladder cancer Cancer Chromosome Mapping Chromosomes, Human, Pair 3 - genetics Female fine mapping Genetic Association Studies Genetic Predisposition to Disease genetic variants Genome-Wide Association Study Genomics Humans Male Medical research MicroRNAs - genetics Middle Aged Polymorphism, Single Nucleotide Risk Factors Transcription Factors - genetics Tumor Suppressor Proteins - genetics Urinary Bladder Neoplasms - genetics Urinary Bladder Neoplasms - pathology
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