Probabilistic cost-effectiveness analysis of cascade screening for familial hypercholesterolaemia using alternative diagnostic and identification strategies

ObjectiveTo estimate the probabilistic cost-effectiveness of cascade screening methods in familial hypercholesterolaemia (FH) from the UK NHS perspective.DesignEconomic evaluation (cost utility analysis) comparing four cascade screening strategies for FH: Using low-density lipoprotein (LDL) choleste...

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Veröffentlicht in:	Heart (British Cardiac Society) 2011-07, Vol.97 (14), p.1175-1181
Hauptverfasser:	Nherera, L, Marks, D, Minhas, R, Thorogood, M, Humphries, S E
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Atherosclerosis Biological and medical sciences Biomarkers - blood Cardiology. Vascular system Cardiovascular disease Cardiovascular Diseases - economics Cardiovascular Diseases - etiology Cardiovascular Diseases - prevention & control cascade testing Cholesterol Cholesterol, LDL - blood Cost-Benefit Analysis Decision trees delivery of care Deoxyribonucleic acid Disorders of blood lipids. Hyperlipoproteinemia DNA DNA testing cost-effectiveness Drug Costs False Negative Reactions False Positive Reactions familial hypercholesterolaemia Family medical history Genetic Predisposition to Disease Genetic testing Genetic Testing - economics genetics Health Care Costs Heredity Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors - economics Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use Hyperlipoproteinemia Type II - blood Hyperlipoproteinemia Type II - complications Hyperlipoproteinemia Type II - diagnosis Hyperlipoproteinemia Type II - drug therapy Hyperlipoproteinemia Type II - economics Hyperlipoproteinemia Type II - genetics lipid lowering Low density lipoprotein Markov Chains Mass Screening - economics Mass Screening - methods Medical sciences Metabolic diseases Methods Middle Aged Models, Economic Mutation Pedigree Predictive Value of Tests Probability Prognosis public health QALY Quality-Adjusted Life Years Sensitivity analysis State Medicine - economics Statins Time Factors United Kingdom
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